AIMC Topic: Knowledge Bases

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Distant Supervision with Transductive Learning for Adverse Drug Reaction Identification from Electronic Medical Records.

Journal of healthcare engineering Sep 26, 2017
Information extraction and knowledge discovery regarding adverse drug reaction (ADR) from large-scale clinical texts are very useful and needy processes. Two major difficulties of this task are the lack of domain experts for labeling examples and int...
Knowledge Bases Software Information Storage and Retrieval Algorithms Medical Informatics Supervised Machine Learning Language Drug-Related Side Effects and Adverse Reactions Natural Language Processing Humans Linear Models Pattern Recognition, Automated Electronic Health Records Adverse Drug Reaction Reporting Systems
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An automatic approach for constructing a knowledge base of symptoms in Chinese.

Journal of biomedical semantics Sep 20, 2017
BACKGROUND: While a large number of well-known knowledge bases (KBs) in life science have been published as Linked Open Data, there are few KBs in Chinese. However, KBs in Chinese are necessary when we want to automatically process and analyze electr...
Automation Disease Knowledge Bases Data Mining Electronic Health Records Medical Informatics Language
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A novel method to identify pre-microRNA in various species knowledge base on various species.

Journal of biomedical semantics Sep 20, 2017
BACKGROUND: More than 1/3 of human genes are regulated by microRNAs. The identification of microRNA (miRNA) is the precondition of discovering the regulatory mechanism of miRNA and developing the cure for genetic diseases. The traditional identificat...
Computational Biology MicroRNAs RNA Precursors Knowledge Bases
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Convex-PL: a novel knowledge-based potential for protein-ligand interactions deduced from structural databases using convex optimization.

Journal of computer-aided molecular design Sep 18, 2017
We present a novel optimization approach to train a free-shape distance-dependent protein-ligand scoring function called Convex-PL. We do not impose any functional form of the scoring function. Instead, we decompose it into a polynomial basis and ded...
Protein Binding Proteins Databases, Protein Molecular Docking Simulation Drug Design Machine Learning Ligands Algorithms Protein Conformation Humans Molecular Structure Binding Sites Structure-Activity Relationship Knowledge Bases
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Knowledge Representation and Management, It's Time to Integrate!

Yearbook of medical informatics Sep 11, 2017
To select, present, and summarize the best papers published in 2016 in the field of Knowledge Representation and Management (KRM). A comprehensive and standardized review of the medical informatics literature was performed based on a PubMed query. ...
Information Storage and Retrieval Vocabulary, Controlled Knowledge Management Knowledge Bases
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The Research of Clinical Decision Support System Based on Three-Layer Knowledge Base Model.

Journal of healthcare engineering Jul 27, 2017
In many clinical decision support systems, a two-layer knowledge base model (disease-symptom) of rule reasoning is used. This model often does not express knowledge very well since it simply infers disease from the presence of certain symptoms. In th...
Bayes Theorem Knowledge Bases Research Decision Support Systems, Clinical Algorithms Decision Support Techniques
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Multi-model-based interactive authoring environment for creating shareable medical knowledge.

Computer methods and programs in biomedicine Jul 22, 2017
OBJECTIVE: Technologically integrated healthcare environments can be realized if physicians are encouraged to use smart systems for the creation and sharing of knowledge used in clinical decision support systems (CDSS). While CDSSs are heading toward...
Clinical Decision-Making Decision Support Systems, Clinical Knowledge Bases Humans
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Knowledge base and mini-expert platform for the diagnosis of inborn errors of metabolism.

Genetics in medicine : official journal of the American College of Medical Genetics Jul 20, 2017
PurposeRecognizing individuals with inherited diseases can be difficult because signs and symptoms often overlap those of common medical conditions. Focusing on inborn errors of metabolism (IEMs), we present a method that brings the knowledge of high...
Medical Informatics Metabolism, Inborn Errors Chromosome Mapping Databases, Genetic Knowledge Bases Expert Testimony Reproducibility of Results ROC Curve Genotype Genetic Association Studies Genetic Predisposition to Disease Algorithms Phenotype Clinical Decision-Making Humans Software
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Learning a Health Knowledge Graph from Electronic Medical Records.

Scientific reports Jul 20, 2017
Demand for clinical decision support systems in medicine and self-diagnostic symptom checkers has substantially increased in recent years. Existing platforms rely on knowledge bases manually compiled through a labor-intensive process or automatically...
Humans Electronic Health Records Knowledge Bases Adult Disease Middle Aged
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DES-TOMATO: A Knowledge Exploration System Focused On Tomato Species.

Scientific reports Jul 20, 2017
Tomato is the most economically important horticultural crop used as a model to study plant biology and particularly fruit development. Knowledge obtained from tomato research initiated improvements in tomato and, being transferrable to other such ec...
Solanum lycopersicum Knowledge Bases Semantics Genes, Plant Genetic Association Studies Information Storage and Retrieval
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