AIMC Topic: Knowledge Bases
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Drug knowledge bases and their applications in biomedical informatics research.
Briefings in bioinformatics
Jul 19, 2019
Recent advances in biomedical research have generated a large volume of drug-related data. To effectively handle this flood of data, many initiatives have been taken to help researchers make good use of them. As the results of these initiatives, many...
Computational functional genomics-based reduction of disease-related gene sets to their key components.
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: The genetic architecture of diseases becomes increasingly known. This raises difficulties in picking suitable targets for further research among an increasing number of candidates. Although expression based methods of gene set reduction a...
Data, Information, and Knowledge.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Apr 1, 2019
Facilitating prediction of adverse drug reactions by using knowledge graphs and multi-label learning models.
Briefings in bioinformatics
Jan 18, 2019
Timely identification of adverse drug reactions (ADRs) is highly important in the domains of public health and pharmacology. Early discovery of potential ADRs can limit their effect on patient lives and also make drug development pipelines more robus...
canSAR: update to the cancer translational research and drug discovery knowledgebase.
Nucleic acids research
Jan 8, 2019
canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs researchers to help solve key bottlenecks in cancer translation and drug discovery. It integrates genom...
Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources.
Nucleic acids research
Jan 8, 2019
The Human Phenotype Ontology (HPO)-a standardized vocabulary of phenotypic abnormalities associated with 7000+ diseases-is used by thousands of researchers, clinicians, informaticians and electronic health record systems around the world. Its detaile...
PreMedKB: an integrated precision medicine knowledgebase for interpreting relationships between diseases, genes, variants and drugs.
Nucleic acids research
Jan 8, 2019
One important aspect of precision medicine aims to deliver the right medicine to the right patient at the right dose at the right time based on the unique 'omics' features of each individual patient, thus maximizing drug efficacy and minimizing adver...
Building a livestock genetic and genomic information knowledgebase through integrative developments of Animal QTLdb and CorrDB.
Nucleic acids research
Jan 8, 2019
Successful development of biological databases requires accommodation of the burgeoning amounts of data from high-throughput genomics pipelines. As the volume of curated data in Animal QTLdb (https://www.animalgenome.org/QTLdb) increases exponentiall...
UniProt: a worldwide hub of protein knowledge.
Nucleic acids research
Jan 8, 2019
The UniProt Knowledgebase is a collection of sequences and annotations for over 120 million proteins across all branches of life. Detailed annotations extracted from the literature by expert curators have been collected for over half a million of the...
Victors: a web-based knowledge base of virulence factors in human and animal pathogens.
Nucleic acids research
Jan 8, 2019
Virulence factors (VFs) are molecules that allow microbial pathogens to overcome host defense mechanisms and cause disease in a host. It is critical to study VFs for better understanding microbial pathogenesis and host defense mechanisms. Victors (ht...
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