AIMC Topic: Membrane Proteins

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Ab-Initio Membrane Protein Amphipathic Helix Structure Prediction Using Deep Neural Networks.

IEEE/ACM transactions on computational biology and bioinformatics Apr 1, 2022
Amphipathic helix (AH)features the segregation of polar and nonpolar residues and plays important roles in many membrane-associated biological processes through interacting with both the lipid and the soluble phases. Although the AH structure has bee...
Machine Learning Algorithms Membrane Proteins Databases, Protein Neural Networks, Computer
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iTTCA-MFF: identifying tumor T cell antigens based on multiple feature fusion.

Immunogenetics Mar 5, 2022
Cancer is a terrible disease, recent studies reported that tumor T cell antigens (TTCAs) may play a promising role in cancer treatment. Since experimental methods are still expensive and time-consuming, it is highly desirable to develop automatic com...
Computational Biology Membrane Proteins Amino Acid Sequence Support Vector Machine Algorithms Mitochondrial Proteins Humans Amino Acids T-Lymphocytes Neoplasms
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An Improved Topology Prediction of Alpha-Helical Transmembrane Protein Based on Deep Multi-Scale Convolutional Neural Network.

IEEE/ACM transactions on computational biology and bioinformatics Feb 3, 2022
Alpha-helical proteins ( αTMPs) are essential in various biological processes. Despite their tertiary structures are crucial for revealing complex functions, experimental structure determination remains challenging and costly. In the past decades, va...
Neural Networks, Computer Membrane Proteins Databases, Protein
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Computed structures of core eukaryotic protein complexes.

Science (New York, N.Y.) Dec 10, 2021
Protein-protein interactions play critical roles in biology, but the structures of many eukaryotic protein complexes are unknown, and there are likely many interactions not yet identified. We take advantage of advances in proteome-wide amino acid coe...
Computer Simulation Deep Learning Protein Interaction Maps Computational Biology Models, Molecular Protein Conformation Saccharomyces cerevisiae Ubiquitin Proteome Membrane Proteins Evolution, Molecular Homologous Recombination Chromosome Segregation Ligases Protein Biosynthesis Ribosomes Multiprotein Complexes Protein Interaction Mapping Acyltransferases Saccharomyces cerevisiae Proteins DNA Repair
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MemDis: Predicting Disordered Regions in Transmembrane Proteins.

International journal of molecular sciences Nov 12, 2021
Transmembrane proteins (TMPs) play important roles in cells, ranging from transport processes and cell adhesion to communication. Many of these functions are mediated by intrinsically disordered regions (IDRs), flexible protein segments without a wel...
Data Mining Intrinsically Disordered Proteins Protein Conformation Reproducibility of Results Computational Biology Membrane Proteins Databases, Protein Models, Molecular Internet Amino Acid Sequence Neural Networks, Computer
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TopProperty: Robust Metaprediction of Transmembrane and Globular Protein Features Using Deep Neural Networks.

Journal of chemical theory and computation Oct 18, 2021
Transmembrane proteins (TMPs) are critical components of cellular life. However, due to experimental challenges, the number of experimentally resolved TMP structures is severely underrepresented in databases compared to their cellular abundance. Pred...
Membrane Proteins Databases, Protein Protein Structure, Secondary Neural Networks, Computer Algorithms Computational Biology
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iMPT-FDNPL: Identification of Membrane Protein Types with Functional Domains and a Natural Language Processing Approach.

Computational and mathematical methods in medicine Oct 11, 2021
Membrane protein is an important kind of proteins. It plays essential roles in several cellular processes. Based on the intramolecular arrangements and positions in a cell, membrane proteins can be divided into several types. It is reported that the ...
Protein Domains Membrane Proteins Humans Support Vector Machine Algorithms Databases, Protein Computational Biology Natural Language Processing
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Highly accurate protein structure prediction for the human proteome.

Nature Jul 22, 2021
Protein structures can provide invaluable information, both for reasoning about biological processes and for enabling interventions such as structure-based drug development or targeted mutagenesis. After decades of effort, 17% of the total residues i...
Diacylglycerol O-Acyltransferase Protein Folding Humans Deep Learning Glucose-6-Phosphatase Computational Biology Reproducibility of Results Models, Molecular Proteome Datasets as Topic Membrane Proteins Protein Conformation
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Accurate prediction of protein structures and interactions using a three-track neural network.

Science (New York, N.Y.) Jul 15, 2021
DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of Structure Prediction (CASP14) conference. We explored network architectures that incorporate related ideas and obtained the best performance with a three-track ...
Protein Subunits Sphingosine N-Acyltransferase Neural Networks, Computer Protein Conformation Cryoelectron Microscopy Proteins Protein Folding Databases, Protein Multiprotein Complexes Receptors, G-Protein-Coupled Amino Acid Sequence Computer Simulation Models, Molecular ADAM Proteins Deep Learning Crystallography, X-Ray Membrane Proteins
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Loop-mediated isothermal amplification (LAMP) and machine learning application for early pregnancy detection using bovine vaginal mucosal membrane.

Biochemical and biophysical research communications Jul 10, 2021
An early and accurate pregnancy diagnosis method is required to improve the reproductive performance of cows. Here we developed an easy pregnancy detection method using vaginal mucosal membrane (VMM) with application of Reverse Transcription-Loop-med...
Machine Learning Cytokines Nucleic Acid Amplification Techniques Biomarkers Pregnancy Adaptor Proteins, Signal Transducing Cattle Gene Expression Reproducibility of Results Female Mucous Membrane Sensitivity and Specificity Vagina RNA-Binding Proteins Animals CA-125 Antigen Molecular Diagnostic Techniques Ubiquitins Membrane Proteins
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