AIMC Topic: Mice

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Effect of clove on improving running ability in aging mice.

Journal of food biochemistry Jul 19, 2022
In this study, a D-galactose-induced aging mouse model was established, and Syringa oblata Lindl. extract (SOLE) was administered orally to observe the effect and mechanism of SOLE on the running ability of aging mice. The role of SOLE was evaluated ...
Galactose Syzygium RNA, Messenger Lactic Acid Plant Extracts Tea Humans Rutin Superoxide Dismutase Tumor Necrosis Factor-alpha Oxidative Stress Animals Mice
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A disector-based framework for the automatic optical fractionator.

Journal of chemical neuroanatomy Jul 15, 2022
Stereology-based methods provide the current state-of-the-art approaches for accurate quantification of numbers and other morphometric parameters of biological objects in stained tissue sections. The advent of artificial intelligence (AI)-based deep ...
Neocortex Cell Count Neurons Humans Artificial Intelligence Animals Mice Algorithms
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Gene function prediction in five model eukaryotes exclusively based on gene relative location through machine learning.

Scientific reports Jul 8, 2022
The function of most genes is unknown. The best results in automated function prediction are obtained with machine learning-based methods that combine multiple data sources, typically sequence derived features, protein structure and interaction data....
Machine Learning Phenotype Drosophila melanogaster Caenorhabditis elegans Genome Mice Saccharomyces cerevisiae Animals
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Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy.

Science translational medicine Jul 6, 2022
Dilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as thinning and enlargement of left ventricular chambers. These characteristics eventually lead to heart failure. Current standards of care do not target the underlying ...
Animals Mice Disease Models, Animal Adaptor Proteins, Signal Transducing Stroke Volume Deep Learning Ventricular Function, Left Histone Deacetylase Inhibitors Apoptosis Regulatory Proteins Heart Failure Cardiomyopathy, Dilated Myocytes, Cardiac
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Single-cell specific and interpretable machine learning models for sparse scChIP-seq data imputation.

PloS one Jul 1, 2022
MOTIVATION: Single-cell Chromatin ImmunoPrecipitation DNA-Sequencing (scChIP-seq) analysis is challenging due to data sparsity. High degree of sparsity in biological high-throughput single-cell data is generally handled with imputation methods that c...
Machine Learning Animals Sequence Analysis, DNA Cluster Analysis Mice DNA Genomics
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Closed-loop transcranial ultrasound stimulation with a fuzzy controller for modulation of motor response and neural activity of mice.

Journal of neural engineering Jun 30, 2022
. We propose a closed-loop transcranial ultrasound stimulation (TUS) with a fuzzy controller to realize real-time and precise control of the motor response and neural activity of mice.. The mean absolute value (MAV) of the electromyogram (EMG) and pe...
Mice Fuzzy Logic Feedback Animals Neural Networks, Computer Computer Simulation
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SDNN-PPI: self-attention with deep neural network effect on protein-protein interaction prediction.

BMC genomics Jun 27, 2022
BACKGROUND: Protein-protein interactions (PPIs) dominate intracellular molecules to perform a series of tasks such as transcriptional regulation, information transduction, and drug signalling. The traditional wet experiment method to obtain PPIs info...
Humans Neural Networks, Computer Protein Interaction Mapping Animals Computational Biology Amino Acid Sequence Mice Saccharomyces cerevisiae
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Microarchitectural Changes of Cardiovascular Calcification in Response to In Vivo Interventions Using Deep-Learning Segmentation and Computed Tomography Radiomics.

Arteriosclerosis, thrombosis, and vascular biology Jun 16, 2022
BACKGROUND: Coronary calcification associates closely with cardiovascular risk, but its progress is accelerated in response to some interventions widely used to reduce risk. This paradox suggests that qualitative, not just quantitative, changes in ca...
Tomography, X-Ray Computed Animals Mice Plaque, Atherosclerotic Deep Learning
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Autonomous push button-controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant.

Science advances Jun 15, 2022
Traceless physical cues are desirable for remote control of the in situ production and real-time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic, magnetogenetic, or electrogenetic devices require sophisticated elect...
Prostheses and Implants Electronics Electric Power Supplies Animals Insulin Mice Humans Artificial Intelligence
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Deep learning for behaviour classification in a preclinical brain injury model.

PloS one Jun 15, 2022
The early detection of traumatic brain injuries can directly impact the prognosis and survival of patients. Preceding attempts to automate the detection and the assessment of the severity of traumatic brain injury continue to be based on clinical dia...
Deep Learning Mice Brain Injuries, Traumatic Machine Learning Algorithms Humans Animals Neural Networks, Computer
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