Lab on a chip
Dec 6, 2022
We present a novel approach for the design of capillary-driven microfluidic networks using a machine learning genetic algorithm (ML-GA). This strategy relies on a user-friendly 1D numerical tool specifically developed to generate the necessary data t...
Analytica chimica acta
Dec 1, 2022
On-site nucleic acid testing (NAT) plays an important role for disease monitoring and pathogen diagnosis. In this work, we developed an automated and fully-integrated nucleic acid analyzer by combining the automated liquid handling robot technique wi...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Nov 22, 2022
Soft robots are envisioned as the next generation of safe biomedical devices in minimally invasive procedures. Yet, the difficulty of processing soft materials currently limits the size, aspect-ratio, manufacturing throughput, as well as, the design ...
Proceedings of the National Academy of Sciences of the United States of America
Nov 7, 2022
Immunocyte infiltration and cytotoxicity play critical roles in both inflammation and immunotherapy. However, current cancer immunotherapy screening methods overlook the capacity of the T cells to penetrate the tumor stroma, thereby significantly lim...
Nature communications
Oct 26, 2022
Liquid manipulation is the foundation of most laboratory processes. For macroscale liquid handling, both do-it-yourself and commercial robotic systems are available; however, for microscale, reagents are expensive and sample preparation is difficult....
Lab on a chip
Oct 25, 2022
Encapsulation of cells inside microfluidic droplets is central to several applications involving cellular analysis. Although, theoretically the encapsulation statistics are expected to follow a Poisson distribution, experimentally this may not be ach...
Langmuir : the ACS journal of surfaces and colloids
Oct 21, 2022
As we all know, chopsticks can hold food, so can we use this method to carry Newtonian fluids such as droplets? This paper studies the process of this transfer and uses this method to realize the manipulation of open microfluidics by robots. To reali...
Small (Weinheim an der Bergstrasse, Germany)
Aug 26, 2022
Nowadays, artificial intelligence (AI) creates numerous promising opportunities in the life sciences. AI methods can be significantly advantageous for analyzing the massive datasets provided by biotechnology systems for biological and biomedical appl...
Proceedings of the National Academy of Sciences of the United States of America
Aug 24, 2022
The next robotics frontier will be led by biohybrids. Capable biohybrid robots require microfluidics to sustain, improve, and scale the architectural complexity of their core ingredient: biological tissues. Advances in microfluidics have already revo...
Lab on a chip
Aug 23, 2022
A major challenge in the field of microfluidics is to predict and control drop interactions. This work develops an image-based data-driven model to forecast drop dynamics based on experiments performed on a microfluidics device. Reduced-order modelli...