AIMC Topic: Microscopy, Atomic Force

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Cellular level robotic surgery: Nanodissection of intermediate filaments in live keratinocytes.

Nanomedicine : nanotechnology, biology, and medicine
We present the nanosurgery on the cytoskeleton of live cells using AFM based nanorobotics to achieve adhesiolysis and mimic the effect of pathophysiological modulation of intercellular adhesion. Nanosurgery successfully severs the intermediate filame...

Automated atomic force microscopy analysis using convolutional and recurrent neural networks.

Biophysical journal
Atomic force microscope (AFM) indentation allows high-resolution spatial characterization of biomechanical properties of cells and tissues. Rapid, reproducible, and quantitative analysis of AFM force curves has been challenging due to several technic...

Multioutput Convolutional Neural Network for Improved Parameter Extraction in Time-Resolved Electrostatic Force Microscopy Data.

Journal of chemical information and modeling
Time-resolved scanning probe microscopy methods, like time-resolved electrostatic force microscopy (trEFM), enable imaging of dynamic processes ranging from ion motion in batteries to electronic dynamics in microstructured thin film semiconductors fo...

Analysis of biofilm assembly by large area automated AFM.

NPJ biofilms and microbiomes
Biofilms are complex microbial communities critical in medical, industrial, and environmental contexts. Understanding their assembly, structure, genetic regulation, interspecies interactions, and environmental responses is key to developing effective...

Stratum corneum nanotexture feature detection using deep learning and spatial analysis: a noninvasive tool for skin barrier assessment.

GigaScience
BACKGROUND: Corneocyte surface nanoscale topography (nanotexture) has recently emerged as a potential biomarker for inflammatory skin diseases, such as atopic dermatitis (AD). This assessment method involves quantifying circular nano-size objects (CN...

Artificial Neural Network-Aided Computational Approach for Mechanophenotyping of Biological Cells Using Atomic Force Microscopy.

Journal of biomechanical engineering
The artificial neural network (ANN) based models have shown the potential to provide alternate data-driven solutions in disease diagnostics, cell sorting and overcoming AFM-related limitations. Hertzian model-based prediction of mechanical properties...

Enabling autonomous scanning probe microscopy imaging of single molecules with deep learning.

Nanoscale
Scanning probe microscopies allow investigating surfaces at the nanoscale, in real space and with unparalleled signal-to-noise ratio. However, these microscopies are not used as much as it would be expected considering their potential. The main limit...

Comparative study of antibacterial activity between Schiff base nicotinic hydrazide derivative and its silver architected nanoparticles with atomic force microscopic study of bacterial cell wall.

Pakistan journal of pharmaceutical sciences
The threat of multi-drug resistant bacterial pathogens evokes researchers to synthesized safe and effective chemotherapeutic agents for nano-drug delivery system. In current study, Schiff base of nicotinic hydrazide(NHD) and its silver nanoparticles(...