AIMC Topic: Microscopy, Atomic Force
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Robot-Guided Atomic Force Microscopy for Mechano-Visual Phenotyping of Cancer Specimens.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
Sep 7, 2015
Atomic force microscopy (AFM) and other forms of scanning probe microscopy have been successfully used to assess biomechanical and bioelectrical characteristics of individual cells. When extending such approaches to heterogeneous tissue, there exists...
Cellular level robotic surgery: Nanodissection of intermediate filaments in live keratinocytes.
Nanomedicine : nanotechnology, biology, and medicine
Sep 6, 2014
We present the nanosurgery on the cytoskeleton of live cells using AFM based nanorobotics to achieve adhesiolysis and mimic the effect of pathophysiological modulation of intercellular adhesion. Nanosurgery successfully severs the intermediate filame...
Enhanced reconstruction of atomic force microscopy cell images to super-resolution.
Journal of microscopy
Aug 1, 2025
Atomic force microscopy (AFM) plays a pivotal role in cell biology research. It enables scientists to observe the morphology of cell surfaces at the nanoscale, providing essential data for understanding cellular functions, including cell-cell interac...
Computer vision techniques for high-speed atomic force microscopy of DNA molecules.
Nanotechnology
Jul 16, 2025
High-speed atomic force microscopy (HSAFM) can produce thousands of topographic, nanoscale images over a small area. One emerging application of this technique is the detection and sizing of single DNA molecules derived from biological experiments an...
Automated atomic force microscopy analysis using convolutional and recurrent neural networks.
Biophysical journal
Jun 17, 2025
Atomic force microscope (AFM) indentation allows high-resolution spatial characterization of biomechanical properties of cells and tissues. Rapid, reproducible, and quantitative analysis of AFM force curves has been challenging due to several technic...
Multioutput Convolutional Neural Network for Improved Parameter Extraction in Time-Resolved Electrostatic Force Microscopy Data.
Journal of chemical information and modeling
Jun 9, 2025
Time-resolved scanning probe microscopy methods, like time-resolved electrostatic force microscopy (trEFM), enable imaging of dynamic processes ranging from ion motion in batteries to electronic dynamics in microstructured thin film semiconductors fo...
Analysis of biofilm assembly by large area automated AFM.
NPJ biofilms and microbiomes
May 8, 2025
Biofilms are complex microbial communities critical in medical, industrial, and environmental contexts. Understanding their assembly, structure, genetic regulation, interspecies interactions, and environmental responses is key to developing effective...
Stratum corneum nanotexture feature detection using deep learning and spatial analysis: a noninvasive tool for skin barrier assessment.
GigaScience
Jan 2, 2024
BACKGROUND: Corneocyte surface nanoscale topography (nanotexture) has recently emerged as a potential biomarker for inflammatory skin diseases, such as atopic dermatitis (AD). This assessment method involves quantifying circular nano-size objects (CN...
Artificial Neural Network-Aided Computational Approach for Mechanophenotyping of Biological Cells Using Atomic Force Microscopy.
Journal of biomechanical engineering
Jul 1, 2023
The artificial neural network (ANN) based models have shown the potential to provide alternate data-driven solutions in disease diagnostics, cell sorting and overcoming AFM-related limitations. Hertzian model-based prediction of mechanical properties...
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