AIMC Topic: Cytoskeleton

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Analysis of 2-dimensional regional differences in the peripapillary scleral fibroblast cytoskeleton of normotensive and hypertensive mouse eyes.

Scientific reports Jul 1, 2025
These studies aimed to study the mechanisms of glaucomatous peripapillary scleral (PPS) remodeling by investigating IOP-induced changes in fibroblast actin-collagen alignment and nuclear morphology in mouse PPS. Cryosections from the optic nerve head...
Disease Models, Animal Mice, Inbred C57BL Fibroblasts Male Mice Cytoskeleton Ocular Hypertension Sclera Collagen Optic Disk Actins Glaucoma Intraocular Pressure Animals
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Deep learning-based cytoskeleton segmentation for accurate high-throughput measurement of cytoskeleton density.

Protoplasma Dec 18, 2024
Microscopic analyses of cytoskeleton organization are crucial for understanding various cellular activities, including cell proliferation and environmental responses in plants. Traditionally, assessments of cytoskeleton dynamics have been qualitative...
Cytoskeleton Arabidopsis Deep Learning Microtubules Nicotiana
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Classification of helical polymers with deep-learning language models.

Journal of structural biology Nov 7, 2023
Many macromolecules in biological systems exist in the form of helical polymers. However, the inherent polymorphism and heterogeneity of samples complicate the reconstruction of helical polymers from cryo-EM images. Currently, available 2D classifica...
Deep Learning Polymers Macromolecular Substances Cryoelectron Microscopy Cytoskeleton
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DBlink: dynamic localization microscopy in super spatiotemporal resolution via deep learning.

Nature methods Jul 27, 2023
Single-molecule localization microscopy (SMLM) has revolutionized biological imaging, improving the spatial resolution of traditional microscopes by an order of magnitude. However, SMLM techniques require long acquisition times, typically a few minut...
Single Molecule Imaging Cytoskeleton Neural Networks, Computer Deep Learning Microscopy
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Modeling and design of heterogeneous hierarchical bioinspired spider web structures using deep learning and additive manufacturing.

Proceedings of the National Academy of Sciences of the United States of America Jul 24, 2023
Spider webs are incredible biological structures, comprising thin but strong silk filament and arranged into complex hierarchical architectures with striking mechanical properties (e.g., lightweight but high strength, achieving diverse mechanical res...
Algorithms Animals Deep Learning Commerce Cytoskeleton Spiders
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Precise measurement of nanoscopic septin ring structures with deep learning-assisted quantitative superresolution microscopy.

Molecular biology of the cell May 20, 2022
The combination of image analysis and superresolution microscopy methods allows for unprecedented insight into the organization of macromolecular assemblies in cells. Advances in deep learning (DL)-based object recognition enable the automated proces...
Cytoskeleton Septins Macromolecular Substances Microscopy Single Molecule Imaging Deep Learning
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Acquiring structural and mechanical information of a fibrous network through deep learning.

Nanoscale Mar 31, 2022
Fibrous networks play an essential role in the structure and properties of a variety of biological and engineered materials, such as cytoskeletons, protein filament-based hydrogels, and entangled or crosslinked polymer chains. Therefore, insight into...
Cytoskeleton Deep Learning Polymers Hydrogels
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A Gas-Ribbon-Hybrid Actuated Soft Finger with Active Variable Stiffness.

Soft robotics Mar 5, 2021
A new hybrid actuated soft finger with active variable stiffness is proposed for the first time by integrating gas-driven and ribbon-driven mechanisms. By carefully coordinating the two mechanisms, the bending deformation and the stiffness modulation...
Equipment Design Fingers Cytoskeleton Robotics
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Identification of contributing genes of Huntington's disease by machine learning.

BMC medical genomics Nov 23, 2020
BACKGROUND: Huntington's disease (HD) is an inherited disorder caused by the polyglutamine (poly-Q) mutations of the HTT gene results in neurodegeneration characterized by chorea, loss of coordination, cognitive decline. However, HD pathogenesis is s...
Nerve Tissue Proteins Sensation Datasets as Topic Linear Models Gene Expression Regulation Humans Inflammation Gene Expression Profiling Cognition Machine Learning Perception Cytoskeleton Prefrontal Cortex Decision Trees Gene Ontology Huntington Disease
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Convolutional neural network for cell classification using microscope images of intracellular actin networks.

PloS one Mar 13, 2019
Automated cell classification is an important yet a challenging computer vision task with significant benefits to biomedicine. In recent years, there have been several studies attempted to build an artificial intelligence-based cell classifier using ...
Microscopy, Fluorescence Models, Statistical Cytoskeleton Reproducibility of Results Breast Machine Learning Pattern Recognition, Automated Cell Line, Tumor Breast Neoplasms MCF-7 Cells Image Processing, Computer-Assisted Humans Automation Cell Line Neural Networks, Computer Algorithms Actins Female Cytoplasm
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