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Microscopy

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Morphological classification of odontogenic keratocysts using Bouligand-Minkowski fractal descriptors.

Computers in biology and medicine
The Odontogenic keratocyst (OKC) is a cystic lesion of the jaws, which has high growth and recurrence rates compared to other cysts of the jaws (for instance, radicular cyst, which is the most common jaw cyst type). For this reason OKCs are considere...

Automatic detection and classification of leukocytes using convolutional neural networks.

Medical & biological engineering & computing
The detection and classification of white blood cells (WBCs, also known as Leukocytes) is a hot issue because of its important applications in disease diagnosis. Nowadays the morphological analysis of blood cells is operated manually by skilled opera...

Convolutional Deep Belief Networks for Single-Cell/Object Tracking in Computational Biology and Computer Vision.

BioMed research international
In this paper, we propose deep architecture to dynamically learn the most discriminative features from data for both single-cell and object tracking in computational biology and computer vision. Firstly, the discriminative features are automatically ...

Machine learning based methodology to identify cell shape phenotypes associated with microenvironmental cues.

Biomaterials
Cell morphology has been identified as a potential indicator of stem cell response to biomaterials. However, determination of cell shape phenotype in biomaterials is complicated by heterogeneous cell populations, microenvironment heterogeneity, and m...

The cellular microscopy phenotype ontology.

Journal of biomedical semantics
BACKGROUND: Phenotypic data derived from high content screening is currently annotated using free-text, thus preventing the integration of independent datasets, including those generated in different biological domains, such as cell lines, mouse and ...

Active machine learning-driven experimentation to determine compound effects on protein patterns.

eLife
High throughput screening determines the effects of many conditions on a given biological target. Currently, to estimate the effects of those conditions on other targets requires either strong modeling assumptions (e.g. similarities among targets) or...

Healthy and unhealthy red blood cell detection in human blood smears using neural networks.

Micron (Oxford, England : 1993)
One of the most common diseases that affect human red blood cells (RBCs) is anaemia. To diagnose anaemia, the following methods are typically employed: an identification process that is based on measuring the level of haemoglobin and the classificati...

Deep Voting: A Robust Approach Toward Nucleus Localization in Microscopy Images.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Robust and accurate nuclei localization in microscopy image can provide crucial clues for accurate computer-aid diagnosis. In this paper, we propose a convolutional neural network (CNN) based hough voting method to localize nucleus centroids with hea...

Interactive Cell Segmentation Based on Active and Semi-Supervised Learning.

IEEE transactions on medical imaging
Automatic cell segmentation can hardly be flawless due to the complexity of image data particularly when time-lapse experiments last for a long time without biomarkers. To address this issue, we propose an interactive cell segmentation method by clas...

An Intelligent Decision Support System for Leukaemia Diagnosis using Microscopic Blood Images.

Scientific reports
This research proposes an intelligent decision support system for acute lymphoblastic leukaemia diagnosis from microscopic blood images. A novel clustering algorithm with stimulating discriminant measures (SDM) of both within- and between-cluster sca...