AIMC Topic: Mitochondria, Liver

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Derivation, characterisation and analysis of an adverse outcome pathway network for human hepatotoxicity.

Toxicology Jul 10, 2021
Adverse outcome pathways (AOPs) and their networks are important tools for the development of mechanistically based non-animal testing approaches, such as in vitro and/or in silico assays, to assess toxicity induced by chemicals. In the present study...
Humans Neural Networks, Computer Computer Simulation Risk Assessment Oxidative Stress Treatment Outcome Cell Death Fatty Acids Chemical and Drug Induced Liver Injury Mitochondria, Liver Adverse Outcome Pathways
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Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.

Archives of toxicology Sep 22, 2016
The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanis...
Humans Artificial Intelligence Animals Severity of Illness Index Oxidative Stress Computational Biology Liver Molecular Structure Lysosomes Models, Biological Expert Systems Evidence-Based Medicine Adaptive Immunity Chemical and Drug Induced Liver Injury Hepatobiliary Elimination Drugs, Investigational Mitochondria, Liver
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