Pathway engineering offers a promising avenue for sustainable chemical production. The design of efficient production systems requires understanding complex host-pathway interactions that shape the metabolic phenotype. While genome-scale metabolic mo...
This study introduces an advanced computational model for simulating surface electromyography (sEMG) signals during muscle contractions. The model integrates five elements that simulate the chain of processes from motor intention to voltage variation...
The increasing prevalence of central nervous system (CNS) disorders has imposed a significant social and economic burden on healthcare systems. The blood-brain barrier (BBB) presents a major challenge for effective drug delivery to the brain, hinderi...
Artificial musculoskeletal systems mimic mammalian biomechanics using antagonistic muscles and rigid skeletons. They offer benefits such as adjustable stiffness, back-drivability, and muscle failure tolerance but are difficult to model and control du...
In this work, we study the nonlinear dynamics of tail motion using numerical simulations and experiments. Our simulations are based on a discrete model comprising rigid cylinders (representing vertebrae) coupled by longitudinal, shear, and bending sp...
Stick insects exhibit remarkable adaptive walking capabilities across diverse environments; however, the mechanisms underlying their gait transitions remain poorly understood. Although reinforcement learning (RL) has been employed to generate insect-...
In response to the urgent issues faced by current bionic undulating fin robot propulsion mechanisms, such as low working efficiency, insufficient swimming speed, ignoring thickness parameters, and the need for further improvement in biomimetic degree...
Biological systems maintain stability of their function in spite of external and internal perturbations. An important challenge in studying biological regulation is to identify the control objectives based on empirical data. Very often these objectiv...
Glioblastoma is among the most aggressive brain tumors in adults, characterized by patient-specific invasion patterns driven by the underlying brain microstructure. In this work, we present a proof-of-concept for a mathematical model of GBL growth, e...
The relationship between morphology and locomotion performance in amphibious fish remains poorly understood, particularly in axial-appendage-based and appendage-based movements. To address this, we introduce Polymander, a reconfigurable robot capable...
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