Breast cancer is a complex and challenging disease to treat, and despite progress in combating it, drug resistance remains a significant hindrance. Drug combinations have shown promising results in improving therapeutic outcomes, and many machine lea...
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...
Breast cancer survival is hard to predict because of the complex ways genes and cells interact. This study offers a new method to improve these predictions by combining gene expression profiling (GEP) with agent-based modeling (ABM). First, GEP will ...
Mammal-inspired quadruped robots excel in traversing diverse terrestrial terrains but often lack aquatic mobility, limiting their effectiveness in amphibious environments. To address this challenge, an amphibious robotic dog (ARD) was developed, inte...
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
May 8, 2025
Since the turn of the millennium, computational modelling of biological systems has evolved remarkably and sees matured use spanning basic and clinical research. While the topic of the peri-millennial debate about the virtues and limitations of 'redu...
Journal of the Royal Society, Interface
May 7, 2025
Seahorses possess a unique tail muscle architecture that enables efficient grasping and anchoring onto objects. This prehensile ability is crucial for their survival, as it allows them to resist currents, cling to mates during reproduction and remain...
Understanding of complex biological systems remains a significant challenge due to their high dimensionality, nonlinearity, and context-specific behavior. Artificial intelligence (AI) and mechanistic modeling are becoming essential tools for studying...
Patellar tendinopathy is prevalent in sports requiring high jumping demands, and understanding the in vivo biomechanical behavior of the patellar tendon (PT) during landing is crucial for developing effective injury prevention and rehabilitation stra...
Entomopathogenic nematodes (EPNs) exhibit a bending-elastic instability, or kink, before becoming airborne, a feature previously hypothesized but not substantiated to enhance jumping performance. Here, we provide the evidence that this kink is crucia...
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