AIMC Topic: Molecular Targeted Therapy

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Prediction of Human Drug Targets and Their Interactions Using Machine Learning Methods: Current and Future Perspectives.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2018
Identification of drug targets and drug target interactions are important steps in the drug-discovery pipeline. Successful computational prediction methods can reduce the cost and time demanded by the experimental methods. Knowledge of putative drug ...
Computational Biology Drug Repositioning Drug Discovery Amino Acid Sequence Molecular Targeted Therapy Supervised Machine Learning Drug Interactions Drug Delivery Systems Humans
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A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.

Current pharmaceutical biotechnology Jan 1, 2017
BACKGROUND: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.
Gene Knockdown Techniques Molecular Targeted Therapy PC12 Cells Aspartic Acid Endopeptidases Animals Humans Blood-Brain Barrier Rats Drug Carriers Permeability Mice, Nude RNA, Small Interfering Drug Delivery Systems Nanoparticles Alzheimer Disease Amyloid Precursor Protein Secretases Neurons
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Some Remarks on Prediction of Drug-Target Interaction with Network Models.

Current topics in medicinal chemistry Jan 1, 2017
System-level understanding of the relationships between drugs and targets is very important for enhancing drug research, especially for drug function repositioning. The experimental methods used to determine drug-target interactions are usually time-...
Algorithms Molecular Docking Simulation Neural Networks, Computer Humans Ion Channels Pharmaceutical Preparations Molecular Targeted Therapy Ligands Receptors, G-Protein-Coupled
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[Hepatic Resection of Multiple Liver Metastases from Gastric Cancer after Molecular Targeted Chemotherapy(S-1 plus Cisplatin plus Trastuzumab)].

Gan to kagaku ryoho. Cancer & chemotherapy Nov 1, 2015
A 62-year-old man was diagnosed with gastric cancer and underwent distal gastrectomy, and D1+b lymph node dissection. He was diagnosed postoperatively with T1b (sm2) N0M0, Stageā… A gastric adenocarcinoma and did not receive any adjuvant chemotherapy a...
Molecular Targeted Therapy Recurrence Hepatectomy Gastrectomy Trastuzumab Cisplatin Lymphatic Metastasis Lymph Node Excision Drug Combinations Treatment Outcome Stomach Neoplasms Antineoplastic Combined Chemotherapy Protocols Humans Tegafur Oxonic Acid Middle Aged Liver Neoplasms Male
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