AI Medical Compendium Topic:
Neurons

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Unsupervised Anomaly Detection in Stream Data with Online Evolving Spiking Neural Networks.

Neural networks : the official journal of the International Neural Network Society
Unsupervised anomaly discovery in stream data is a research topic with many practical applications. However, in many cases, it is not easy to collect enough training data with labeled anomalies for supervised learning of an anomaly detector in order ...

Dynamics of a Large-Scale Spiking Neural Network with Quadratic Integrate-and-Fire Neurons.

Neural plasticity
Since the high dimension and complexity of the large-scale spiking neural network, it is difficult to research the network dynamics. In recent decades, the mean-field approximation has been a useful method to reduce the dimension of the network. In t...

Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning.

PLoS computational biology
Phenotypic profiling of large three-dimensional microscopy data sets has not been widely adopted due to the challenges posed by cell segmentation and feature selection. The computational demands of automated processing further limit analysis of hard-...

Bioinspired multisensory neural network with crossmodal integration and recognition.

Nature communications
The integration and interaction of vision, touch, hearing, smell, and taste in the human multisensory neural network facilitate high-level cognitive functionalities, such as crossmodal integration, recognition, and imagination for accurate evaluation...

Machine learning identifies candidates for drug repurposing in Alzheimer's disease.

Nature communications
Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA) for another indication i...

Biomimetic FPGA-based spatial navigation model with grid cells and place cells.

Neural networks : the official journal of the International Neural Network Society
The mammalian spatial navigation system is characterized by an initial divergence of internal representations, with disparate classes of neurons responding to distinct features including location, speed, borders and head direction; an ensuing converg...

Real-time volumetric reconstruction of biological dynamics with light-field microscopy and deep learning.

Nature methods
Light-field microscopy has emerged as a technique of choice for high-speed volumetric imaging of fast biological processes. However, artifacts, nonuniform resolution and a slow reconstruction speed have limited its full capabilities for in toto extra...

Automatic deep learning-driven label-free image-guided patch clamp system.

Nature communications
Patch clamp recording of neurons is a labor-intensive and time-consuming procedure. Here, we demonstrate a tool that fully automatically performs electrophysiological recordings in label-free tissue slices. The automation covers the detection of cell...

Modulation of the dynamics of cerebellar Purkinje cells through the interaction of excitatory and inhibitory feedforward pathways.

PLoS computational biology
The dynamics of cerebellar neuronal networks is controlled by the underlying building blocks of neurons and synapses between them. For which, the computation of Purkinje cells (PCs), the only output cells of the cerebellar cortex, is implemented thro...

A new recursive least squares-based learning algorithm for spiking neurons.

Neural networks : the official journal of the International Neural Network Society
Spiking neural networks (SNNs) are regarded as effective models for processing spatio-temporal information. However, their inherent complexity of temporal coding makes it an arduous task to put forward an effective supervised learning algorithm, whic...