Autophagy is a fundamental cellular process that is well conserved among eukaryotes. It is one of the strategies that cells use to catabolize substances in a controlled way. Autophagy is used for recycling cellular components, responding to cellular ...
Tremor is a commonly observed symptom in patients of Parkinson's disease (PD), and accurate measurement of tremor severity is essential in prescribing appropriate treatment to relieve its symptoms. We propose a tremor assessment system based on the u...
European journal of nuclear medicine and molecular imaging
Dec 23, 2017
PURPOSE: This work aimed to assess the potential of a set of features extracted from [I]FP-CIT SPECT brain images to be used in the computer-aided "in vivo" confirmation of dopaminergic degeneration and therefore to assist clinical decision to diagno...
International journal of nanomedicine
Dec 14, 2017
The aggregation of alpha-synuclein (αS), natively unstructured presynaptic protein, is a crucial factor leading to the pathogenesis of Parkinson's disease (PD) and other related disorders. Recent studies have shown prefibrillar and oligomeric interme...
OBJECTIVES: Various exercise strategies have been suggested to address movement deficits in order to improve motor function and quality of life for individuals in the early or moderate stages of Parkinson disease. The purpose is to evaluate the effec...
Neural networks : the official journal of the International Neural Network Society
Dec 7, 2017
The efficacy of deep brain stimulation (DBS) for Parkinson's disease (PD) depends in part on the post-operative programming of stimulation parameters. Closed-loop stimulation is one method to realize the frequent adjustment of stimulation parameters....
IEEE transactions on bio-medical engineering
Dec 4, 2017
OBJECTIVE: The study of gait in Parkinson's disease is important because it can provide insights into the complex neural system and physiological behaviors of the disease, of which understanding can help improve treatment and lead to effective develo...
IEEE journal of biomedical and health informatics
Nov 27, 2017
The goal of this study was to develop an algorithm that automatically quantifies motor states (off, on, dyskinesia) in Parkinson's disease (PD), based on accelerometry during a hand pronation-supination test. Clinician's ratings using the Treatment R...
Computer methods and programs in biomedicine
Nov 16, 2017
BACKGROUND AND OBJECTIVE: A new expert system is proposed to discriminate healthy people from people with Parkinson's Disease (PD) in early stages by using Diadochokinesis tests.
MOTIVATION: Although clinical aspirations for new technology to accurately measure and diagnose Parkinsonian tremors exist, automatic scoring of tremor severity using machine learning approaches has not yet been employed.
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