BACKGROUND: Concentrations of outdoor ultrafine particles (UFP; <0.1 µm) and black carbon (BC) can vary greatly within cities and long-term exposures to these pollutants have been associated with a variety of adverse health outcomes.
Visible and subvisible particles are a quality attribute in sterile pharmaceutical samples. A common method for characterizing and quantifying pharmaceutical samples containing particulates is imaging many individual particles using high-throughput i...
International journal of pharmaceutics
May 20, 2023
The purpose of this study is to demonstrate the usefulness of machine learning (ML) for analyzing a material attribute database from tablets produced at different granulation scales. High shear wet granulators (scale 30 g and 1000 g) were used and da...
International journal of pharmaceutics
Apr 11, 2023
A recently developed process analytical technology (PAT) using artificial intelligence to form the framework of its model, combining frequency-domain acoustic emissions (AE) and elastic impact mechanics to accurately predict complex particle size dis...
Colloidal particles can attach to surfaces during transport, but the attachment depends on particle size, hydrodynamics, solid and water chemistry, and particulate matter. The attachment is quantified in filtration theory by measuring attachment or s...
Quality risk management is an important task when it pertains to the pharmaceutical industry, as this is directly related to product performance. With the ICH Q9 guidelines, several regulatory bodies have encouraged the pharmaceutical industry to imp...
The transport and retention of microorganisms are typically described using attachment/detachment and straining/liberation models. However, the parameters in the models varied significantly, posing a significant challenge to describe microbial transp...
Container choice can influence particle generation within protein formulations. Incompatibility between proteins and containers can manifest as increased particle concentrations, shifts in particle size distributions and changes in particle morpholog...
Dynamic Light Scattering is a well-established technique used in particle sizing. An alternative procedure for Dynamic Light Scattering time series processing based on spectral entropy computation and Artificial Neural Networks is described. An error...
Drug development and industrial pharmacy
May 19, 2022
OBJECTIVE: The present study was aimed to design and optimize brimonidine tartrate (BRT) loaded cationic-charged liposome formulation with enhanced trans-corneal drug permeation, prolonged corneal residence, and sustained drug release for effective o...
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