AIMC Topic: Phosphorylation
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Computational Phosphorylation Network Reconstruction: An Update on Methods and Resources.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2021
Most proteins undergo some form of modification after translation, and phosphorylation is one of the most relevant and ubiquitous post-translational modifications. The succession of protein phosphorylation and dephosphorylation catalyzed by protein k...
DeepPhos: prediction of protein phosphorylation sites with deep learning.
Bioinformatics (Oxford, England)
Aug 15, 2019
MOTIVATION: Phosphorylation is the most studied post-translational modification, which is crucial for multiple biological processes. Recently, many efforts have been taken to develop computational predictors for phosphorylation site prediction, but m...
Capsule network for protein post-translational modification site prediction.
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Computational methods for protein post-translational modification (PTM) site prediction provide a useful approach for studying protein functions. The prediction accuracy of the existing methods has significant room for improvement. A rece...
A generic deep convolutional neural network framework for prediction of receptor-ligand interactions-NetPhosPan: application to kinase phosphorylation prediction.
Bioinformatics (Oxford, England)
Apr 1, 2019
MOTIVATION: Understanding the specificity of protein receptor-ligand interactions is pivotal for our comprehension of biological mechanisms and systems. Receptor protein families often have a certain level of sequence diversity that converges into fe...
iPTMnet: an integrated resource for protein post-translational modification network discovery.
Nucleic acids research
Jan 4, 2018
Protein post-translational modifications (PTMs) play a pivotal role in numerous biological processes by modulating regulation of protein function. We have developed iPTMnet (http://proteininformationresource.org/iPTMnet) for PTM knowledge discovery, ...
[Interleukin?22 promotes proliferation of fibroblast?like synoviocytes from patients with rheumatoid arthritis by inducing STAT3 phosphorylation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Dec 20, 2017
OBJECTIVE: To clarify the mechanism by which interleukin?22 (IL?22) promotes the proliferation of fibroblast?like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).
MusiteDeep: a deep-learning framework for general and kinase-specific phosphorylation site prediction.
Bioinformatics (Oxford, England)
Dec 15, 2017
MOTIVATION: Computational methods for phosphorylation site prediction play important roles in protein function studies and experimental design. Most existing methods are based on feature extraction, which may result in incomplete or biased features. ...
Rapid Communication: Prolactin and hydrocortisone impact TNFα-mediated mitogen-activated protein kinase signaling and inflammation of bovine mammary epithelial (MAC-T) cells.
Journal of animal science
Dec 1, 2017
The objective of this study was to evaluate the effects of the hormones prolactin (PRL) and hydrocortisone (HC) on bovine mammary alveolar (MAC-T) cells mitogen-activated protein kinase (MAPK) inflammatory signaling and inflammatory gene expression. ...
[Y-27632 protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy pathway].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Nov 1, 2017
Objective To investigate the protective effect of preconditioning with Rho-kinase inhibitor Y-27632 on H9c2 cardiomyocytes against hypoxia/reoxygenation (H/R) injury, and explore its underlying mechanism. Methods H9c2 cardiomyocytes were divided into...
iMulti-HumPhos: a multi-label classifier for identifying human phosphorylated proteins using multiple kernel learning based support vector machines.
Molecular bioSystems
Jul 25, 2017
Protein phosphorylation plays a potential role in regulating protein conformation and functions. As a result, identifying an uncharacterized protein sequence as a phosphorylated protein is a very meaningful problem and an urgent issue for both basic ...
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