AIMC Topic: STAT3 Transcription Factor
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Ultrahigh-Throughput Virtual Screening Strategies against PPI Targets: A Case Study of STAT Inhibitors.
Journal of chemical information and modeling
Jul 4, 2025
In recent years, virtual screening of ultralarge (10) libraries of synthetically accessible compounds (uHTVS) became a popular approach in hit identification. With AI-assisted virtual screening workflows, such as Deep Docking, these protocols might b...
Therapeutic Mechanisms of Medicine Food Homology Plants in Alzheimer's Disease: Insights from Network Pharmacology, Machine Learning, and Molecular Docking.
International journal of molecular sciences
Feb 27, 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a gradual decline in cognitive function. Currently, there are no effective treatments for this condition. Medicine food homology plants have gained increasing atten...
Identification of STAT3 phosphorylation inhibitors using generative deep learning, virtual screening, molecular dynamics simulations, and biological evaluation for non-small cell lung cancer therapy.
Molecular diversity
Dec 23, 2024
The development of phosphorylation-suppressing inhibitors targeting Signal Transducer and Activator of Transcription 3 (STAT3) represents a promising therapeutic strategy for non-small cell lung cancer (NSCLC). In this study, a generative model was d...
Exploring putative drug properties associated with TNF-alpha inhibition and identification of potential targets in cardiovascular disease using machine learning-assisted QSAR modeling and virtual reverse pharmacology approach.
Molecular diversity
Jul 2, 2024
Cardiovascular disease is a chronic inflammatory disease with high mortality rates. TNF-alpha is pro-inflammatory and associated with the disease, but current medications have adverse effects. Therefore, efficient inhibitors are urgently needed as al...
Long non-coding RNAs in biomarking COVID-19: a machine learning-based approach.
Virology journal
Jun 7, 2024
BACKGROUND: The coronavirus pandemic that started in 2019 has caused the highest mortality and morbidity rates worldwide. Data on the role of long non-coding RNAs (lncRNAs) in coronavirus disease 2019 (COVID-19) is scarce. We aimed to elucidate the r...
Analysis of the improvement effect of Astragalus extract on oxidative stress injury in viral myocarditis through STAT3/IL-6.
Cellular and molecular biology (Noisy-le-Grand, France)
Dec 31, 2023
The objective of this study was to investigate the improvement effect of Astragalus (AS) extract on oxidative stress (OS) and inflammatory response of myocarditis (MYO) cells through the STAT3/IL-6 axis. For this purpose, The MYO model cells prepared...
A novel artificial intelligence protocol for finding potential inhibitors of acute myeloid leukemia.
Journal of materials chemistry. B
Feb 18, 2020
There is currently no effective treatment for acute myeloid leukemia, and surgery is also ineffective as an important treatment for most tumors. Rapidly developing artificial intelligence technology can be applied to different aspects of drug develop...
Investigation of the mutagenic and genotoxic activities of LLL-3, a STAT3 inhibitor.
Drug and chemical toxicology
Apr 10, 2016
LLL-3, an anthracene derived compound, has been shown to be a promising therapeutic agent for the treatment of some kinds of cancer such as chronic myeloid leukemia and glioblastoma. However, no data regarding the toxic properties of this compound ha...
Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.
Arteriosclerosis, thrombosis, and vascular biology
Mar 10, 2016
OBJECTIVE: Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical impli...
Phenotype
Computer Simulation
Animals
Gene Expression Profiling
Case-Control Studies
Coronary Artery Disease
Genome-Wide Association Study
STAT3 Transcription Factor
Protein Interaction Maps
Genetic Loci
Gene Regulatory Networks
Computational Biology
Lumican
Gene Expression Regulation
Humans
Signal Transduction
Mice
Neural Networks, Computer
Databases, Genetic
Genomics
Bayes Theorem
Genetic Predisposition to Disease
[Interleukin?22 promotes proliferation of fibroblast?like synoviocytes from patients with rheumatoid arthritis by inducing STAT3 phosphorylation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Dec 20, 2017
OBJECTIVE: To clarify the mechanism by which interleukin?22 (IL?22) promotes the proliferation of fibroblast?like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).
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