Proteomics experiments often generate a vast amount of data. However, the simple identification and quantification of proteins from a cell proteome or subproteome is not sufficient for the full understanding of complex mechanisms occurring in the bio...
Platelet-type von Willebrand disease (PT-VWD) refers to a rare bleeding disorder caused by gain-of-function mutations in platelet glycoprotein Ibα (GPIbα). These mutations lead to a hyperactive protein-protein interaction (PPI) with von Willebrand fa...
Protein-protein interactions (PPIs) are ubiquitous mediators of cellular functions, and their dysregulation is central to numerous pathological conditions. Traditional drug discovery strategies targeting PPIs directly have faced considerable obstacle...
Schistosomiasis, caused by Schistosoma mansoni, remains a significant public health burden, particularly in endemic regions with limited access to effective treatment. The emergence of resistance to praziquantel necessitates the urgent discovery of n...
In vertebrates, antibody-mediated immunity is a vital component of the immune system, and antibodies have become a rapidly expanding class of therapeutic agents. Nanobodies, a distinct type of antibody, have recently emerged as a stable and cost-effe...
Protein science : a publication of the Protein Society
Sep 1, 2025
Mesothelin (MSLN) is a cell surface glycoprotein overexpressed in many solid tumors, which is known to interact with cancer antigen CA125/MUC16, promoting cancer cell adhesion and metastasis. MSLN has been used as a target of multiple antibody-based ...
Structural data provides important information on the proteins' function. Recent development of advanced machine learning and artificial intelligence tools, such as AlphaFold, have led to an explosion of predicted protein structures. However, many of...
Journal of molecular graphics & modelling
Sep 1, 2025
Parkinson's disease is a neurodegenerative condition that affects the brain's neurons, and causes malfunction of nerve cells and their death. A neurotransmitter called dopamine interacts with the part of the brain in charge of coordination and moveme...
Journal of chemical information and modeling
Aug 11, 2025
Noncoding RNAs (ncRNAs) interact with proteins, playing a crucial role in regulating gene expression and cellular functions. Accurate prediction of these interactions is essential for understanding biological processes and developing novel therapeuti...
Computer methods and programs in biomedicine
Aug 1, 2025
BACKGROUND AND OBJECTIVE: T cells play a vital role in the immune system by recognizing and eliminating infected or cancerous cells, thus driving adaptive immune responses. Their activation is triggered by the binding of T cell receptors (TCRs) to ep...
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