The detection of mixed-species bacterial samples plays a vital role in ensuring food safety, yet research in this area remains notably limited. This study investigates the integration of MALDI-TOF MS-derived peptidome profiles with artificial intelli...
Rapid and reliable peptide identification techniques are essential for proteomics. High-resolution tandem mass spectrometry acquires a large amount of data through data-dependent acquisition (DDA) and data-independent acquisition (DIA), but tradition...
BACKGROUND: The complex pathogenesis of Alzheimer's disease (AD) has resulted in limited current biomarkers for its classification and diagnosis, necessitating further investigation into reliable universal biomarkers or combinations.
Cerebral infarction (CI) is a leading cause of disability and mortality, with activated plasma monocytes and altered protein glycosylation identified as critical contributors to its pathology. However, the mechanisms linking peripheral monocyte activ...
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Plasma proteomics provides a unique opportunity to enhance disease prediction by capturing protein expression patterns linked to diverse pathological processes. Leveraging data from 2,923 proteins measured in 53,030 UK Biobank participants, we develo...
The current depth of site-specific N-glycoproteomics is insufficient to fully characterize glycosylation events in biological samples. Herein, we achieve an ultradeep and precision analysis of the N-glycoproteome of mouse tissues by integrating multi...
Metabolomics : Official journal of the Metabolomic Society
Jul 1, 2025
INTRODUCTION: Data normalization is crucial for multi-omics integration, reducing systematic errors and maximizing the likelihood of discovering true biological variation. Most studies assess normalization for a single omics type or use datasets from...
Recent advances in spatially resolved single-omic and multi-omics technologies have led to the emergence of computational tools to detect and predict spatial domains. Additionally, histological images and immunofluorescence (IF) staining of proteins ...
Blood-based biomarkers in epilepsy could constitute important research tools advancing neurobiological understanding and valuable clinical tools for better diagnosis and follow-up. An interesting question is whether biomarker patterns could contribut...
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