INTRODUCTION: Physical activity (PA) is crucial for older adults' well-being and mitigating health risks. Encouraging active lifestyles requires a deeper understanding of the factors influencing PA, which conventional approaches often overlook by ass...
Therapeutic innovation & regulatory science
May 13, 2025
BACKGROUND: As described in ICH E3 Q&A R1 (International Council for Harmonisation. E3: Structure and content of clinical study reports-questions and answers (R1). 6 July 2012. Available from: https://database.ich.org/sites/default/files/E3_Q%26As_R1...
PURPOSE OF REVIEW: Despite the pivotal role of randomized controlled trials (RCTs) in critical care research, many have failed to demonstrate significant benefits, particularly in nutrition interventions. This review highlights how patient heterogene...
INTRODUCTION: Perinatal depression and anxiety (PDA) is associated with a high risk of maternal mortality. Existing data shows that 95% of maternal mortality in low- and middle-income countries (LMICs) is due to resource constraints and negligence in...
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Apr 14, 2025
The field of rare cancer research is rapidly transforming, marked by significant progress in clinical trials and treatment strategies. Rare cancers, as defined by the National Cancer Institute, occur in fewer than 150 cases per million people each ye...
BACKGROUND: Social robots (SR), sensorimotor machines designed to interact with humans, can help to respond to the increasing demands in the health care sector. To ensure the successful use of this technology, acceptance is paramount. Generative arti...
BACKGROUND: Randomised controlled trials (RCTs) commonly estimate intention-to-treat (ITT) estimands. However, when nonadherence to assigned treatment occurs, ITT estimands reflect the effect of being offered treatment, rather than adhering to it and...
INTRODUCTION: Musculoskeletal disorders (MSDs) represent a significant global health burden that leads to substantial disability with socioeconomic impact. With the rise of artificial intelligence (AI), particularly large language model-driven conver...
OBJECTIVES: Adherence to established reporting guidelines can improve clinical trial reporting standards, but attempts to improve adherence have produced mixed results. This exploratory study aimed to determine how accurate a large language model gen...
INTRODUCTION: Methods to adopt artificial intelligence (AI) in healthcare clinical practice remain unclear. The potential for rapid integration of AI-enabled technologies across healthcare settings coupled with the growing digital divide in the healt...
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