AI Medical Compendium Topic:
Research Design

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Combined application of mixture experimental design and artificial neural networks in the solid dispersion development.

Drug development and industrial pharmacy
This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus®-poloxamer 188 SDs were prepared by solven...

Adaptive Neural Output Feedback Control of Output-Constrained Nonlinear Systems With Unknown Output Nonlinearity.

IEEE transactions on neural networks and learning systems
This paper addresses the problem of adaptive neural output-feedback control for a class of special nonlinear systems with the hysteretic output mechanism and the unmeasured states. A modified Bouc-Wen model is first employed to capture the output hys...

Laparoscopic and Robotic-assisted Vesicovaginal Fistula Repair: A Systematic Review of the Literature.

Journal of minimally invasive gynecology
Two types of laparoscopic or robotic-assisted vesicovaginal fistula (VVF) repairs, the traditional transvesical (O'Conor) and extravesical techniques, dominate the literature. The objectives of this study are to compare success rates between laparosc...

Use of uniform designs in combination with neural networks for viral infection process development.

Biotechnology progress
This work aimed to compare the predictive capacity of empirical models, based on the uniform design utilization combined to artificial neural networks with respect to classical factorial designs in bioprocess, using as example the rabies virus replic...

Secondary use of electronic health records for building cohort studies through top-down information extraction.

Journal of biomedical informatics
Controlled clinical trials are usually supported with an in-front data aggregation system, which supports the storage of relevant information according to the trial context within a highly structured environment. In contrast to the documentation of c...

Citations alone were enough to predict favorable conclusions in reviews of neuraminidase inhibitors.

Journal of clinical epidemiology
OBJECTIVES: To examine the use of supervised machine learning to identify biases in evidence selection and determine if citation information can predict favorable conclusions in reviews about neuraminidase inhibitors.

A multi-technique approach to bridge electronic case report form design and data standard adoption.

Journal of biomedical informatics
BACKGROUND AND OBJECTIVE: The importance of data standards when integrating clinical research data has been recognized. The common data element (CDE) is a consensus-based data element for data harmonization and sharing between clinical researchers, i...

Analysis of eligibility criteria clusters based on large language models for clinical trial design.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVES: Clinical trials (CTs) are essential for improving patient care by evaluating new treatments' safety and efficacy. A key component in CT protocols is the study population defined by the eligibility criteria. This study aims to evaluate the...

Core Concepts in Pharmacoepidemiology: Principled Use of Artificial Intelligence and Machine Learning in Pharmacoepidemiology and Healthcare Research.

Pharmacoepidemiology and drug safety
Artificial intelligence (AI) and machine learning (ML) are important tools across many fields of health and medical research. Pharmacoepidemiologists can bring essential methodological rigor and study design expertise to the design and use of these t...