AIMC Topic: RNA, Long Noncoding

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SFPEL-LPI: Sequence-based feature projection ensemble learning for predicting LncRNA-protein interactions.

PLoS computational biology Dec 11, 2018
LncRNA-protein interactions play important roles in post-transcriptional gene regulation, poly-adenylation, splicing and translation. Identification of lncRNA-protein interactions helps to understand lncRNA-related activities. Existing computational ...
Protein Binding Computational Biology RNA-Binding Proteins Humans Machine Learning Algorithms Base Sequence Databases, Nucleic Acid RNA Processing, Post-Transcriptional RNA, Long Noncoding Databases, Protein Amino Acid Sequence
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Deep learning identifies genome-wide DNA binding sites of long noncoding RNAs.

RNA biology Nov 28, 2018
Long noncoding RNAs (lncRNAs) can exert their function by interacting with the DNA via triplex structure formation. Even though this has been validated with a handful of experiments, a genome-wide analysis of lncRNA-DNA binding is needed. In this pap...
Mice RNA, Long Noncoding DNA Gene Expression Regulation Binding Sites Animals Humans Deep Learning Reproducibility of Results Genome-Wide Association Study
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Gene Ontology-based function prediction of long non-coding RNAs using bi-random walk.

BMC medical genomics Nov 20, 2018
BACKGROUND: With the development of sequencing technology, more and more long non-coding RNAs (lncRNAs) have been identified. Some lncRNAs have been confirmed that they play an important role in the process of development through the dosage compensat...
Humans Algorithms Computational Biology MicroRNAs RNA, Long Noncoding Stomach Neoplasms Protein Interaction Maps Gene Regulatory Networks Proteins Gene Ontology
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Prediction of LncRNA Subcellular Localization with Deep Learning from Sequence Features.

Scientific reports Nov 6, 2018
Long non-coding RNAs are involved in biological processes throughout the cell including the nucleus, chromatin and cytosol. However, most lncRNAs remain unannotated and functional annotation of lncRNAs is difficult due to their low conservation and t...
Computational Biology Humans Sequence Analysis, RNA Cell Line RNA, Long Noncoding Neural Networks, Computer Deep Learning Biological Transport Intracellular Space
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Accurate prediction of protein-lncRNA interactions by diffusion and HeteSim features across heterogeneous network.

BMC bioinformatics Oct 11, 2018
BACKGROUND: Identifying the interactions between proteins and long non-coding RNAs (lncRNAs) is of great importance to decipher the functional mechanisms of lncRNAs. However, current experimental techniques for detection of lncRNA-protein interaction...
RNA, Long Noncoding Computer Simulation RNA-Binding Proteins Databases, Genetic Neural Networks, Computer
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Data mining of the cancer-related lncRNAs GO terms and KEGG pathways by using mRMR method.

Mathematical biosciences Aug 4, 2018
LncRNAs plays an important role in the regulation of gene expression. Identification of cancer-related lncRNAs GO terms and KEGG pathways is great helpful for revealing cancer-related functional biological processes. Therefore, in this study, we prop...
Models, Genetic RNA, Long Noncoding Data Mining Gene Expression Regulation Gene Ontology Databases, Factual Neoplasms Computational Biology Humans
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Identification of 170 New Long Noncoding RNAs in .

BioMed research international Jul 11, 2018
Long noncoding RNAs (lncRNAs) are transcripts generally longer than 200 nucleotides with no or poor protein coding potential, and most of their functions are also poorly characterized. Recently, an increasing number of studies have shown that lncRNAs...
Male Gene Expression Profiling Mice Female Animals Humans RNA, Long Noncoding Exons Gene Ontology Schistosoma mansoni Genome
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HLPI-Ensemble: Prediction of human lncRNA-protein interactions based on ensemble strategy.

RNA biology Jun 6, 2018
LncRNA plays an important role in many biological and disease progression by binding to related proteins. However, the experimental methods for studying lncRNA-protein interactions are time-consuming and expensive. Although there are a few models des...
Databases, Nucleic Acid Humans Support Vector Machine RNA, Long Noncoding Models, Biological RNA-Binding Proteins Sequence Analysis, RNA
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Annotating Diseases Using Human Phenotype Ontology Improves Prediction of Disease-Associated Long Non-coding RNAs.

Journal of molecular biology May 24, 2018
Recently, many long non-coding RNAs (lncRNAs) have been identified and their biological function has been characterized; however, our understanding of their underlying molecular mechanisms related to disease is still limited. To overcome the limitati...
Humans Algorithms Phenotype Reproducibility of Results Neoplasms Gene Ontology RNA, Long Noncoding Disease Molecular Sequence Annotation Gene Regulatory Networks Computational Biology Databases, Genetic
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Prediction of plant lncRNA by ensemble machine learning classifiers.

BMC genomics May 2, 2018
BACKGROUND: In plants, long non-protein coding RNAs are believed to have essential roles in development and stress responses. However, relative to advances on discerning biological roles for long non-protein coding RNAs in animal systems, this RNA cl...
RNA, Plant Machine Learning Computational Biology RNA, Long Noncoding Stochastic Processes Open Reading Frames
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