AIMC Topic: RNA

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Rapid and accurate identification of ribosomal RNA sequences via deep learning.

Nucleic acids research
Advances in transcriptomic and translatomic techniques enable in-depth studies of RNA activity profiles and RNA-based regulatory mechanisms. Ribosomal RNA (rRNA) sequences are highly abundant among cellular RNA, but if the target sequences do not inc...

A tool for feature extraction from biological sequences.

Briefings in bioinformatics
With the advances in sequencing technologies, a huge amount of biological data is extracted nowadays. Analyzing this amount of data is beyond the ability of human beings, creating a splendid opportunity for machine learning methods to grow. The metho...

S2Snet: deep learning for low molecular weight RNA identification with nanopore.

Briefings in bioinformatics
Ribonucleic acid (RNA) is a pivotal nucleic acid that plays a crucial role in regulating many biological activities. Recently, one study utilized a machine learning algorithm to automatically classify RNA structural events generated by a Mycobacteriu...

RNAI-FRID: novel feature representation method with information enhancement and dimension reduction for RNA-RNA interaction.

Briefings in bioinformatics
Different ribonucleic acids (RNAs) can interact to form regulatory networks that play important role in many life activities. Molecular biology experiments can confirm RNA-RNA interactions to facilitate the exploration of their biological functions, ...

PST-PRNA: prediction of RNA-binding sites using protein surface topography and deep learning.

Bioinformatics (Oxford, England)
MOTIVATION: Protein-RNA interactions play essential roles in many biological processes, including pre-mRNA processing, post-transcriptional gene regulation and RNA degradation. Accurate identification of binding sites on RNA-binding proteins (RBPs) i...

UFold: fast and accurate RNA secondary structure prediction with deep learning.

Nucleic acids research
For many RNA molecules, the secondary structure is essential for the correct function of the RNA. Predicting RNA secondary structure from nucleotide sequences is a long-standing problem in genomics, but the prediction performance has reached a platea...

Protein-RNA interaction prediction with deep learning: structure matters.

Briefings in bioinformatics
Protein-RNA interactions are of vital importance to a variety of cellular activities. Both experimental and computational techniques have been developed to study the interactions. Because of the limitation of the previous database, especially the lac...

DeepDISOBind: accurate prediction of RNA-, DNA- and protein-binding intrinsically disordered residues with deep multi-task learning.

Briefings in bioinformatics
Proteins with intrinsically disordered regions (IDRs) are common among eukaryotes. Many IDRs interact with nucleic acids and proteins. Annotation of these interactions is supported by computational predictors, but to date, only one tool that predicts...

NmRF: identification of multispecies RNA 2'-O-methylation modification sites from RNA sequences.

Briefings in bioinformatics
2'-O-methylation (Nm) is a post-transcriptional modification of RNA that is catalyzed by 2'-O-methyltransferase and involves replacing the H on the 2'-hydroxyl group with a methyl group. The 2'-O-methylation modification site is detected in a variety...