BACKGROUND: In the field of computational personalized medicine, drug response prediction (DRP) is a critical issue. However, existing studies often characterize drugs as strings, a representation that does not align with the natural description of m...
Effective and precise mammalian transcriptome engineering technologies are needed to accelerate biological discovery and RNA therapeutics. Despite the promise of programmable CRISPR-Cas13 ribonucleases, their utility has been hampered by an incomplet...
As a prevalent RNA modification, 5-methyluridine (mU) plays a critical role in diverse biological processes and disease pathogenesis. High-throughput identification of mU typically relies on labor-intensive biochemical experiments using various seque...
MOTIVATION: N4-acetylcytidine (ac4C) is a highly conserved RNA modification that plays a crucial role in various biological processes. Accurately identifying ac4C sites is of paramount importance for gaining a deeper understanding of their regulatory...
Interdisciplinary sciences, computational life sciences
Nov 17, 2023
Circular RNA is a single-stranded RNA with a closed-loop structure. In recent years, academic research has revealed that circular RNAs play critical roles in biological processes and are related to human diseases. The discovery of potential circRNAs ...
BACKGROUND: Single-stranded nucleic acids (ssNAs) have important biological roles and a high biotechnological potential linked to their ability to bind to numerous molecular targets. This depends on the different spatial conformations they can assume...
Nowadays there are numerous discovered natural RNA variations participating in different cellular processes and artificial RNA, e. g., aptamers, riboswitches. One of the required tasks in the investigation of their functions and mechanism of influenc...
BACKGROUND: N6, 2'-O-dimethyladenosine (mAm) is an abundant RNA methylation modification on vertebrate mRNAs and is present in the transcription initiation region of mRNAs. It has recently been experimentally shown to be associated with several human...
When analyzing data from in situ RNA detection technologies, cell segmentation is an essential step in identifying cell boundaries, assigning RNA reads to cells, and studying the gene expression and morphological features of cells. We developed a dee...
Fast and accurate 3D RNA structure prediction remains a major challenge in structural biology, mostly due to the size and flexibility of RNA molecules, as well as the lack of diverse experimentally determined structures of RNA molecules. Unlike DNA s...