AIMC Topic: Sequence Analysis, DNA

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Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference.

mSphere
The human microbiome, the community of microorganisms that reside on and inside the human body, is critically important for health and disease. However, it is influenced by various factors and may vary among individuals residing in distinct geographi...

TExCNN: Leveraging Pre-Trained Models to Predict Gene Expression from Genomic Sequences.

Genes
BACKGROUND/OBJECTIVES: Understanding the relationship between DNA sequences and gene expression levels is of significant biological importance. Recent advancements have demonstrated the ability of deep learning to predict gene expression levels direc...

Ense-i6mA: Identification of DNA N-Methyladenine Sites Using XGB-RFE Feature Selection and Ensemble Machine Learning.

IEEE/ACM transactions on computational biology and bioinformatics
DNA N-methyladenine (6mA) is an important epigenetic modification that plays a vital role in various cellular processes. Accurate identification of the 6mA sites is fundamental to elucidate the biological functions and mechanisms of modification. How...

Transcription Factor Binding Site Prediction Using CnNet Approach.

IEEE/ACM transactions on computational biology and bioinformatics
Controlling the gene expression is the most important development in a living organism, which makes it easier to find different kinds of diseases and their causes. It's very difficult to know what factors control the gene expression. Transcription Fa...

Self-distillation improves self-supervised learning for DNA sequence inference.

Neural networks : the official journal of the International Neural Network Society
Self-supervised Learning (SSL) has been recognized as a method to enhance prediction accuracy in various downstream tasks. However, its efficacy for DNA sequences remains somewhat constrained. This limitation stems primarily from the fact that most e...

AI-driven feature selection and epigenetic pattern analysis: A screening strategy of CpGs validated by pyrosequencing for body fluid identification.

Forensic science international
Identification of body fluid stain at crime scene is one of the important tasks of forensic evidence analysis. Currently, body fluid-specific CpGs detected by DNA methylation microarray screening, have been widely studied for forensic body fluid iden...

Developing a method for predicting DNA nucleosomal sequences using deep learning.

Technology and health care : official journal of the European Society for Engineering and Medicine
BackgroundDeep learning excels at processing raw data because it automatically extracts and classifies high-level features. Despite biology's low popularity in data analysis, incorporating computer technology can improve biological research.Objective...

Visualization Methods for DNA Sequences: A Review and Prospects.

Biomolecules
The efficient analysis and interpretation of biological sequence data remain major challenges in bioinformatics. Graphical representation, as an emerging and effective visualization technique, offers a more intuitive method for analyzing DNA sequence...

Deep learning enables the use of ultra-high-density array in DNBSEQ.

Scientific reports
DNBSEQ employs a patterned array to facilitate massively parallel sequencing of DNA nanoballs (DNBs), leading to a considerable boost in throughput. By employing the ultra-high-density (UHD) array with an increased density of DNB binding sites, the t...

Effect of graphene electrode functionalization on machine learning-aided single nucleotide classification.

Nanoscale
Solid-state nanogap-based DNA sequencing with a quantum tunneling approach has emerged as a promising avenue due to its potential to deliver swift and precise sequencing outcomes. Nevertheless, despite significant progress, experimentally achieving s...