Cancer immunotherapy hinges on accurate epitope prediction for advancing vaccine development. VaxOptiML (available at https://vaxoptiml.streamlit.app/ ) is an integrated pipeline designed to enhance epitope prediction and prioritization. This study a...
BACKGROUND: Atrial Fibrillation (AF) is the most common form of arrhythmia in the world with a prevalence of 1%-2%. AF is also associated with an increased risk of cardiovascular diseases (CVD), such as stroke, heart failure, and coronary artery dise...
BACKGROUND: Continuous waveform monitoring is standard-of-care for patients at risk for or with critically illness. Derived from waveforms, heart rate, respiratory rate and blood pressure variability contain useful diagnostic and prognostic informati...
AD is a progressive neurodegenerative disorder characterized by memory loss. Due to the advancement in next-generation sequencing, an enormous amount of AD-associated genomics data is available. However, the information about the involvement of these...
Journal of computer-aided molecular design
Dec 5, 2024
Molecular machine learning (ML) has proven important for tackling various molecular problems, such as predicting molecular properties based on molecular descriptors or fingerprints. Since relatively recently, graph neural network (GNN) algorithms hav...
Convolutional neural network (CNN)-based deep learning (DL) methods have transformed the analysis of geospatial, Earth observation, and geophysical data due to their ability to model spatial context information at multiple scales. Such methods are es...
OBJECTIVES: Large language models (LLMs) are increasingly being used today and are becoming increasingly important for providing accurate clinical information to patients and physicians. This study aimed to evaluate the effectiveness of generative pr...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Dec 3, 2024
Radiopharmaceutical cocktails have been developed over the years to treat cancer. Cocktails of agents are attractive because 1 radiopharmaceutical is unlikely to have the desired therapeutic effect because of nonuniform uptake by the targeted cells. ...
We present MoCHI, a tool to fit interpretable models using deep mutational scanning data. MoCHI infers free energy changes, as well as interaction terms (energetic couplings) for specified biophysical models, including from multimodal phenotypic data...
Journal of magnetic resonance (San Diego, Calif. : 1997)
Nov 29, 2024
In this study, we introduce a denoising method aimed at improving the contrast ratio in low-field MRI (LFMRI) using an advanced 3D deep convolutional residual network model. Our approach employs synthetic brain imaging datasets that closely mimic the...