AIMC Topic: Sunitinib
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Web-Based Explainable Machine Learning-Based Drug Surveillance for Predicting Sunitinib- and Sorafenib-Associated Thyroid Dysfunction: Model Development and Validation Study.
JMIR formative research
Apr 10, 2025
BACKGROUND: Unlike one-snap data collection methods that only identify high-risk patients, machine learning models using time-series data can predict adverse events and aid in the timely management of cancer.
Comparing Scientific Machine Learning With Population Pharmacokinetic and Classical Machine Learning Approaches for Prediction of Drug Concentrations.
CPT: pharmacometrics & systems pharmacology
Feb 7, 2025
A variety of classical machine learning (ML) approaches has been developed over the past decade aiming to individualize drug dosages based on measured plasma concentrations. However, the interpretability of these models is challenging as they do not ...
Machine-learning and mechanistic modeling of metastatic breast cancer after neoadjuvant treatment.
PLoS computational biology
May 3, 2024
Clinical trials involving systemic neoadjuvant treatments in breast cancer aim to shrink tumors before surgery while simultaneously allowing for controlled evaluation of biomarkers, toxicity, and suppression of distant (occult) metastatic disease. Ye...
Autoencoder techniques for survival analysis on renal cell carcinoma.
PloS one
Jan 1, 2025
Survival is the gold standard in oncology when determining the real impact of therapies in patients outcome. Thus, identifying molecular predictors of survival (like genetic alterations or transcriptomic patterns of gene expression) is one of the mos...
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