Supervised methods are increasingly used to identify cell populations in single-cell data. Yet, current methods are limited in their ability to learn from multiple datasets simultaneously, are hampered by the annotation of datasets at different resol...
IEEE journal of biomedical and health informatics
May 11, 2021
Digital histopathology image segmentation can facilitate computer-assisted cancer diagnostics. Given the difficulty of obtaining manual annotations, weak supervision is more suitable for the task than full supervision is. However, most weakly supervi...
BACKGROUND: One challenge to train deep convolutional neural network (CNNs) models with whole slide images (WSIs) is providing the required large number of costly, manually annotated image regions. Strategies to alleviate the scarcity of annotated da...
International journal of computer assisted radiology and surgery
May 6, 2021
PURPOSE: One in five women who undergo breast conserving surgery will need a second revision surgery due to remaining tumor. The iKnife is a mass spectrometry modality that produces real-time margin information based on the metabolite signatures in s...
Neural networks : the official journal of the International Neural Network Society
May 5, 2021
At present, the diversity of data acquisition boosts the growth of multi-view data and the lack of label information. Since manually labeling is expensive and impractical, it is practical to enhance learning performance with a small amount of labeled...
Biological processes are inherently continuous, and the chance of phenotypic discovery is significantly restricted by discretising them. Using multi-parametric active regression we introduce the Regression Plane (RP), a user-friendly discovery tool e...
Primary aldosteronism (PA) is associated with an increased risk of cardiometabolic diseases, especially in unilateral subtype. Despite its high prevalence, the case detection rate of PA is limited, partly because of no clinical models available in ge...
Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic or...
Oral bioavailability (F) is an essential determinant for the systemic exposure and dosing regimens of drug candidates. F is determined by numerous processes, and computational predictions of human estimates have so far shown limited results. We descr...
Equilibrium phase diagrams serve as blueprints for rational design of nanostructured materials of block copolymers, but their construction is time-consuming and requires profound expertise. Herein, by virtue of the knowledge of self-consistent field ...
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