AIMC Topic: Tandem Mass Spectrometry
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DiagnoProt: a tool for discovery of new molecules by mass spectrometry.
Bioinformatics (Oxford, England)
Jun 15, 2017
MOTIVATION: Around 75% of all mass spectra remain unidentified by widely adopted proteomic strategies. We present DiagnoProt, an integrated computational environment that can efficiently cluster millions of spectra and use machine learning to shortli...
Comparative study between UHPLC-UV and UPLC-MS/MS methods for determination of alogliptin and metformin in their pharmaceutical combination.
Die Pharmazie
Feb 1, 2017
A new UPLC-MS/MS method (method A), for simultaneous determination of alogliptin (ALN) and metformin (MET) in their recently approved pharmaceutical combination Kazano® tablets, was developed and compared to a new UHPLC-UV method (method B). Concerni...
STABILITY INDICATIVE HPLC DETERMINATION OF RELATED SUBSTANCES AND IDENTIFICATION OF POTENTIAL DEGRADANTS USING LC-MS IN TRIPLE COMBINATION ANTIRETROVIRAL TABLETS.
Acta poloniae pharmaceutica
Jan 1, 2017
A rapid stability indicating liquid chromatography method was developed and validated for the simultaneous quantitation of related substances of antiretrovirals in combined oral dosage formulation. Separation was achieved using a Waters, Xterra RP-18...
Therapeutic Drug Monitoring of Phenytoin by Simple, Rapid, Accurate, Highly Sensitive and Novel Method and Its Clinical Applications.
Current pharmaceutical biotechnology
Jan 1, 2017
BACKGROUND: Phenytoin has very challenging pharmacokinetic properties. To prevent its toxicity and ensure efficacy, continuous therapeutic monitoring is required. It is hard to get a simple, accurate, rapid, easily available, economical and highly se...
[Tetrodotoxin (TTX) Monitoring of Biological Specimens and Toxin Profile in a Food Poisoning Case Caused by the Scavenging Gastropod Nassarius (Alectrion) glans "Kinshibai"].
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan
Jan 1, 2017
In November 2015, a patient presented with symptoms of toxicity after eating whole boiled samples of the scavenging gastropod Nassarius (Alectrion) glans "Kinshibai" in Nagasaki. This food poisoning case was the third recorded in Japan. The case was ...
Fast metabolite identification with Input Output Kernel Regression.
Bioinformatics (Oxford, England)
Jun 15, 2016
MOTIVATION: An important problematic of metabolomics is to identify metabolites using tandem mass spectrometry data. Machine learning methods have been proposed recently to solve this problem by predicting molecular fingerprint vectors and matching t...
The effects of sternal intraosseous and intravenous administration of amiodarone in a hypovolemic swine cardiac arrest model.
American journal of disaster medicine
Jan 1, 2016
OBJECTIVE: This study compared the effects of amiodarone via sternal intraosseous (SIO) and intravenous (IV) routes on return of spontaneous circulation (ROSC), time to ROSC, concentration maximum (C), time to maximum concentration (T), and mean conc...
The effects of tibial intraosseous versus intravenous amiodarone administration in a hypovolemic cardiac arrest procine model.
American journal of disaster medicine
Jan 1, 2016
OBJECTIVE: This study compared the effects of amiodarone via tibial intraosseous (TIO) and intravenous (IV) routes on return of spontaneous circulation (ROSC), time to ROSC, maximum drug concentration (Cmax), time to maximum concentration (Tmax), and...
The effects of sternal and intravenous vasopressin administration on pharmacokinetics.
American journal of disaster medicine
Jan 1, 2016
OBJECTIVE: Purposes of this study were to compare intravenous (IV) and sternal intraosseous (SIO) administration of vasopressin relative to concentration maximum (Cmax), time to maximum concentration (Tmax), and mean concentration in a cardiac arrest...
Prospective Studies
Animals
Male
Chromatography, High Pressure Liquid
Tandem Mass Spectrometry
Vasoconstrictor Agents
Random Allocation
Swine
Disease Models, Animal
Infusions, Intravenous
Heart Arrest
Infusions, Intraosseous
Sternum
Vasopressins
Multivariate Analysis
Sus scrofa
Cardiopulmonary Resuscitation
[Determination of Triptolide and Wilforlide A in Biological Samples by LC-MS/MS].
Fa yi xue za zhi
Dec 1, 2015
OBJECTIVE: To determinate triptolide and wilforlide A in biological samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method and to verify the method.
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