AIMC Topic: tau Proteins
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Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Sep 3, 2024
Alzheimer disease (AD) exhibits spatially heterogeneous 3- or 4-repeat tau deposition across participants. Our overall goal was to develop an automated method to quantify the heterogeneous burden of tau deposition into a single number that would be c...
Significance of plasma p-tau217 in predicting long-term dementia risk in older community residents: Insights from machine learning approaches.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Aug 8, 2024
INTRODUCTION: Whether plasma biomarkers play roles in predicting incident dementia among the general population is worth exploring.
XAI-Based Assessment of the AMURA Model for Detecting Amyloid-β and Tau Microstructural Signatures in Alzheimer's Disease.
IEEE journal of translational engineering in health and medicine
Jul 17, 2024
Brain microstructural changes already occur in the earliest phases of Alzheimer's disease (AD) as evidenced in diffusion magnetic resonance imaging (dMRI) literature. This study investigates the potential of the novel dMRI Apparent Measures Using Red...
Exploring Tau Fibril-Disaggregating and Antioxidating Molecules Binding to Membrane-Bound Amyloid Oligomers Using Machine Learning-Enhanced Docking and Molecular Dynamics.
Molecules (Basel, Switzerland)
Jun 13, 2024
Intracellular tau fibrils are sources of neurotoxicity and oxidative stress in Alzheimer's. Current drug discovery efforts have focused on molecules with tau fibril disaggregation and antioxidation functions. However, recent studies suggest that memb...
Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis.
Journal of chemical theory and computation
Mar 19, 2024
The ordered assembly of Tau protein into filaments characterizes Alzheimer's and other neurodegenerative diseases, and thus, stabilization of Tau protein is a promising avenue for tauopathies therapy. To dissect the underlying aggregation mechanisms ...
Deep learning application for the classification of Alzheimer's disease using F-flortaucipir (AV-1451) tau positron emission tomography.
Scientific reports
May 19, 2023
The positron emission tomography (PET) with F-flortaucipir can distinguish individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) from cognitively unimpaired (CU) individuals. This study aimed to evaluate the utility of F-flort...
A unique color-coded visualization system with multimodal information fusion and deep learning in a longitudinal study of Alzheimer's disease.
Artificial intelligence in medicine
Apr 7, 2023
PURPOSE: Automated diagnosis and prognosis of Alzheimer's Disease remain a challenging problem that machine learning (ML) techniques have attempted to resolve in the last decade. This study introduces a first-of-its-kind color-coded visualization mec...
Artificial intelligence assisted identification of potential tau aggregation inhibitors: ligand- and structure-based virtual screening, in silico ADME, and molecular dynamics study.
Molecular diversity
Apr 6, 2023
Alzheimer's disease (AD) is a severe, growing, multifactorial disorder affecting millions of people worldwide characterized by cognitive decline and neurodegeneration. The accumulation of tau protein into paired helical filaments is one of the major ...
Diagnosis of Alzheimer Disease and Tauopathies on Whole-Slide Histopathology Images Using a Weakly Supervised Deep Learning Algorithm.
Laboratory investigation; a journal of technical methods and pathology
Mar 6, 2023
Neuropathologic assessment during autopsy is the gold standard for diagnosing neurodegenerative disorders. Neurodegenerative conditions, such as Alzheimer disease (AD) neuropathological change, are a continuous process from normal aging rather than c...
Mapping the association between tau-PET and Aβ-amyloid-PET using deep learning.
Scientific reports
Aug 30, 2022
In Alzheimer's disease, the molecular pathogenesis of the extracellular Aβ-amyloid (Aβ) instigation of intracellular tau accumulation is poorly understood. We employed a high-resolution PET scanner, with low detection thresholds, to examine the Aβ-ta...
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