AIMC Topic: Tissue Plasminogen Activator
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Risk Factors and Outcomes of Hemorrhagic Transformation in Acute Ischemic Stroke Following Thrombolysis: Analysis of a Single-Center Experience and Review of the Literature.
Medicina (Kaunas, Lithuania)
Apr 14, 2025
: This is a retrospective study conducted at the Clinical County Hospital of Craiova, Romania, providing valuable insights into hemorrhagic transformation (HT) in thrombolyzed patients with acute ischemic stroke (AIS). Hemorrhagic complications remai...
Machine learning-based predictive model for the development of thrombolysis resistance in patients with acute ischemic stroke.
BMC neurology
Aug 26, 2024
BACKGROUND: The objective of this study was to establish a predictive model utilizing machine learning techniques to anticipate the likelihood of thrombolysis resistance (TR) in acute ischaemic stroke (AIS) patients undergoing recombinant tissue plas...
A weakly supervised deep learning model integrating noncontrasted computed tomography images and clinical factors facilitates haemorrhagic transformation prediction after intravenous thrombolysis in acute ischaemic stroke patients.
Biomedical engineering online
Dec 19, 2023
BACKGROUND: Haemorrhage transformation (HT) is a serious complication of intravenous thrombolysis (IVT) in acute ischaemic stroke (AIS). Accurate and timely prediction of the risk of HT before IVT may change the treatment decision and improve clinica...
Adaptive wireless millirobotic locomotion into distal vasculature.
Nature communications
Aug 1, 2022
Microcatheters have enabled diverse minimally invasive endovascular operations and notable health benefits compared with open surgeries. However, with tortuous routes far from the arterial puncture site, the distal vascular regions remain challenging...
Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume.
Journal of neuroimaging : official journal of the American Society of Neuroimaging
Apr 17, 2022
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) and intraventricular hemorrhage (IVH) clinical trials rely on manual linear and semi-quantitative (LSQ) estimators like the ABC/2, modified Graeb and IVH scores for timely volumetric estimation f...
Real-Time Ultrasound Doppler Tracking and Autonomous Navigation of a Miniature Helical Robot for Accelerating Thrombolysis in Dynamic Blood Flow.
ACS nano
Jan 4, 2022
Untethered small-scale robots offer great promise for medical applications in complex biological environments. However, challenges remain in the control and medical imaging of a robot for targeted delivery inside a living body, especially in flowing ...
First-in-Human Robot-Assisted Subretinal Drug Delivery Under Local Anesthesia.
American journal of ophthalmology
Nov 14, 2021
PURPOSE: To report the results of a first-in-human study using a robotic device to assist subretinal drug delivery in patients undergoing vitreoretinal surgery for macular hemorrhage.
Artificial neural network based prediction of postthrombolysis intracerebral hemorrhage and death.
Scientific reports
Nov 25, 2020
Despite the salient benefits of the intravenous tissue plasminogen activator (tPA), symptomatic intracerebral hemorrhage (sICH) remains a frequent complication and constitutes a major concern when treating acute ischemic stroke (AIS). This study expl...
Bioinspired Soft Microrobots with Precise Magneto-Collective Control for Microvascular Thrombolysis.
Advanced materials (Deerfield Beach, Fla.)
May 20, 2020
New-era soft microrobots for biomedical applications need to mimic the essential structures and collective functions of creatures from nature. Biocompatible interfaces, intelligent functionalities, and precise locomotion control in a collective manne...
Can clinical audits be enhanced by pathway simulation and machine learning? An example from the acute stroke pathway.
BMJ open
Sep 17, 2019
OBJECTIVE: To evaluate the application of clinical pathway simulation in machine learning, using clinical audit data, in order to identify key drivers for improving use and speed of thrombolysis at individual hospitals.
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