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Tissue Plasminogen Activator

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Correlation between Immune-Inflammatory Markers and Clinical Features in Patients with Acute Ischemic Stroke.

Acta neurologica Taiwanica
OBJECTIVE: Chronic inflammatory processes involving the vascular wall may induce atherosclerosis. Immune-inflammatory processes proceed throughout all stages of acute stroke. We investigated the association of three immune-inflammatory markers, namel...

Risk Factors and Outcomes of Hemorrhagic Transformation in Acute Ischemic Stroke Following Thrombolysis: Analysis of a Single-Center Experience and Review of the Literature.

Medicina (Kaunas, Lithuania)
: This is a retrospective study conducted at the Clinical County Hospital of Craiova, Romania, providing valuable insights into hemorrhagic transformation (HT) in thrombolyzed patients with acute ischemic stroke (AIS). Hemorrhagic complications remai...

Artificial neural network based prediction of postthrombolysis intracerebral hemorrhage and death.

Scientific reports
Despite the salient benefits of the intravenous tissue plasminogen activator (tPA), symptomatic intracerebral hemorrhage (sICH) remains a frequent complication and constitutes a major concern when treating acute ischemic stroke (AIS). This study expl...

First-in-Human Robot-Assisted Subretinal Drug Delivery Under Local Anesthesia.

American journal of ophthalmology
PURPOSE: To report the results of a first-in-human study using a robotic device to assist subretinal drug delivery in patients undergoing vitreoretinal surgery for macular hemorrhage.

Real-Time Ultrasound Doppler Tracking and Autonomous Navigation of a Miniature Helical Robot for Accelerating Thrombolysis in Dynamic Blood Flow.

ACS nano
Untethered small-scale robots offer great promise for medical applications in complex biological environments. However, challenges remain in the control and medical imaging of a robot for targeted delivery inside a living body, especially in flowing ...

Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume.

Journal of neuroimaging : official journal of the American Society of Neuroimaging
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) and intraventricular hemorrhage (IVH) clinical trials rely on manual linear and semi-quantitative (LSQ) estimators like the ABC/2, modified Graeb and IVH scores for timely volumetric estimation f...

Adaptive wireless millirobotic locomotion into distal vasculature.

Nature communications
Microcatheters have enabled diverse minimally invasive endovascular operations and notable health benefits compared with open surgeries. However, with tortuous routes far from the arterial puncture site, the distal vascular regions remain challenging...

A weakly supervised deep learning model integrating noncontrasted computed tomography images and clinical factors facilitates haemorrhagic transformation prediction after intravenous thrombolysis in acute ischaemic stroke patients.

Biomedical engineering online
BACKGROUND: Haemorrhage transformation (HT) is a serious complication of intravenous thrombolysis (IVT) in acute ischaemic stroke (AIS). Accurate and timely prediction of the risk of HT before IVT may change the treatment decision and improve clinica...

Machine learning-based predictive model for the development of thrombolysis resistance in patients with acute ischemic stroke.

BMC neurology
BACKGROUND: The objective of this study was to establish a predictive model utilizing machine learning techniques to anticipate the likelihood of thrombolysis resistance (TR) in acute ischaemic stroke (AIS) patients undergoing recombinant tissue plas...

Machine Learning Model Predictors of Intrapleural Tissue Plasminogen Activator and DNase Failure in Pleural Infection: A Multicenter Study.

Annals of the American Thoracic Society
Intrapleural enzyme therapy (IET) with tissue plasminogen activator (tPA) and DNase has been shown to reduce the need for surgical intervention for complicated parapneumonic effusion/empyema (CPPE/empyema). Failure of IET may lead to delayed care an...