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Vascular Endothelial Growth Factor A

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Deep learning for the prediction of early on-treatment response in metastatic colorectal cancer from serial medical imaging.

Nature communications 34789774
In current clinical practice, tumor response assessment is usually based on tumor size change on serial computerized tomography (CT) scan images. However, evaluation of tumor response to anti-vascular endothelial growth factor therapies in metastatic...
Antineoplastic Combined Chemotherapy Protocols Colorectal Neoplasms Deep Learning Humans Predictive Value of Tests Prognosis Retrospective Studies Tomography, X-Ray Computed Treatment Outcome Vascular Endothelial Growth Factor A
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Identification of Potential Drug Therapy for Dermatofibrosarcoma Protuberans with Bioinformatics and Deep Learning Technology.

Current computer-aided drug design 35975851
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare mesenchymal tumor that is primarily treated with surgery. Targeted therapy is a promising approach to help reduce the high rate of recurrence. This study aims to identify the potential targ...
Computational Biology Deep Learning Dermatofibrosarcoma Gene Expression Profiling Humans Receptors, Platelet-Derived Growth Factor Skin Neoplasms Technology Vascular Endothelial Growth Factor A
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Clinically applicable deep learning-based decision aids for treatment of neovascular AMD.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 35064365
PURPOSE: Anti-vascular endothelial growth factor (Anti-VEGF) therapy is currently seen as the standard for treatment of neovascular AMD (nAMD). However, while treatments are highly effective, decisions for initial treatment and retreatment are often ...
Angiogenesis Inhibitors Artificial Intelligence Decision Support Techniques Deep Learning Humans Tomography, Optical Coherence Vascular Endothelial Growth Factor A Visual Acuity Wet Macular Degeneration
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Breaking the ageing paradigm in endometrium: endometrial gene expression related to cilia and ageing hallmarks in women over 35 years.

Human reproduction (Oxford, England) 35085395
STUDY QUESTION: Does age affect endometrial gene expression?
Aging Artificial Intelligence Cilia Endometrium Female Humans Reproducibility of Results Retrospective Studies Transcriptome Vascular Endothelial Growth Factor A
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Therapeutic response in the HAWK and HARRIER trials using deep learning in retinal fluid volume and compartment analysis.

Eye (London, England) 35523860
OBJECTIVES: To assess the therapeutic response to brolucizumab and aflibercept by deep learning/OCT-based analysis of macular fluid volumes in neovascular age-related macular degeneration.
Angiogenesis Inhibitors Deep Learning Humans Intravitreal Injections Ranibizumab Retinal Detachment Subretinal Fluid Tomography, Optical Coherence Vascular Endothelial Growth Factor A Wet Macular Degeneration
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Correlation of vascular and fluid-related parameters in neovascular age-related macular degeneration using deep learning.

Acta ophthalmologica 35912717
PURPOSE: To identify correlations between the vascular characteristics of macular neovascularization (MNV) obtained by optical coherence tomography angiography (OCTA) and distinct retinal fluid volumes in neovascular age-related macular degeneration ...
Angiogenesis Inhibitors Deep Learning Fluorescein Angiography Humans Intravitreal Injections Macular Degeneration Prospective Studies Tomography, Optical Coherence Vascular Endothelial Growth Factor A Wet Macular Degeneration
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Establishing the Controlled Delivery of VEGF Using a Hydrogel Loaded Soft Robotic Drug Delivery System With the Aim to Prevascularise Implant Site for Islet Transplantation: Erratum.

Transplantation 36436105
Drug Delivery Systems Hydrogels Islets of Langerhans Transplantation Robotics Vascular Endothelial Growth Factor A
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KFWC: A Knowledge-Driven Deep Learning Model for Fine-grained Classification of Wet-AMD.

Computer methods and programs in biomedicine 36584638
BACKGROUND AND OBJECTIVES: Automated diagnosis using deep neural networks can help ophthalmologists detect the blinding eye disease wet Age-related Macular Degeneration (AMD). Wet-AMD has two similar subtypes, Neovascular AMD and Polypoidal Choroidal...
Angiogenesis Inhibitors Deep Learning Fluorescein Angiography Fundus Oculi Humans Polypoidal Choroidal Vasculopathy Tomography, Optical Coherence Vascular Endothelial Growth Factor A Visual Acuity Wet Macular Degeneration
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Interpretable attention-based deep learning ensemble for personalized ovarian cancer treatment without manual annotations.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society 37075618
Inhibition of pathological angiogenesis has become one of the first FDA approved targeted therapies widely tested in anti-cancer treatment, i.e. VEGF-targeting monoclonal antibody bevacizumab, in combination with chemotherapy for frontline and mainte...
Angiopoietin-2 Antibodies, Monoclonal, Humanized Bevacizumab Deep Learning Female Humans Ovarian Neoplasms Pyruvate Kinase Vascular Endothelial Growth Factor A
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Performance of retinal fluid monitoring in OCT imaging by automated deep learning versus human expert grading in neovascular AMD.

Eye (London, England) 37311835
PURPOSE: To evaluate the reliability of automated fluid detection in identifying retinal fluid activity in OCT scans of patients treated with anti-VEGF therapy for neovascular age-related macular degeneration by correlating human expert and automated...
Angiogenesis Inhibitors Deep Learning Humans Intravitreal Injections Reproducibility of Results Subretinal Fluid Tomography, Optical Coherence Vascular Endothelial Growth Factor A Visual Acuity Wet Macular Degeneration
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