Methods in molecular biology (Clifton, N.J.)
Jan 1, 2018
The analysis of proteomics data can be significantly challenging. Beyond the technical challenges of accurately identifying and quantifying peptides, identifying the most biologically coherent set of biomarkers can be a particularly daunting step. In...
Cardiovascular imaging technologies continue to increase in their capacity to capture and store large quantities of data. Modern computational methods, developed in the field of machine learning, offer new approaches to leveraging the growing volume ...
Journal of computational biology : a journal of computational molecular cell biology
Aug 1, 2017
Contemporary workflow management systems are driven by explicit process models specifying the interdependencies between tasks. Creating these models is a challenging and time-consuming task. Existing approaches to mining concrete workflows into model...
MOTIVATION: Bioinformatic analyses are becoming formidably more complex due to the increasing number of steps required to process the data, as well as the proliferation of methods that can be used in each step. To alleviate this difficulty, pipelines...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2017
Src homology 2 (SH2) domain is an important subclass of modular protein domains that plays an indispensable role in several biological processes in eukaryotes. SH2 domains specifically bind to the phosphotyrosine residue of their binding peptides to ...
N-Myristoyltransferase (NMT) catalyzes the transfer of myristate to the amino-terminal glycine of a subset of proteins, a co-translational modification involved in trafficking substrate proteins to membrane locations, stabilization and protein-protei...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2016
Identifying adenylation domains (A-domains) and their substrate specificity can aid the detection of nonribosomal peptide synthetases (NRPS) at genome/proteome level and allow inferring the structure of oligopeptides with relevant biological activiti...
Studies in health technology and informatics
Jan 1, 2015
The emerging penetration of Health IT in Latin America (especially in Brazil) has exacerbated the ever-increasing amount of Electronic Health Record (EHR) clinical free text documents.This imposes a workflow efficiency challenge on clinicians who nee...