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Acute Coronary Syndrome

Latest AI and machine learning research in acute coronary syndrome for healthcare professionals.

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Automated Phenotypic Characterization in Rare Hematologic Malignancies Using a Large Language Model-Based Framework

Background. Diagnosis and risk stratification in rare hematologic malignancies such as myeloproliferative neoplasms (MPNs) - polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF) - require expert review of longitudinal, heterogeneous clinical records. This process is cognitively demanding, inconsistently applied, and difficult to scale beyond tertiary centers. No automated...

Multi-omics and network propagation reveal latent innate immune programmes stratifying high-risk thrombotic primary antiphospholipid syndrome

Thrombotic primary antiphospholipid syndrome (thrPAPS) outcomes are associated with thrombosis type (arterial versus venous), recurrence, and antiphospholipid antibody (aPL) profile (single versus triple-aPL). We investigated molecular signatures underlying disease status and high-risk phenotypes. We performed whole-blood transcriptomics and mass spectrometry-based plasma proteomics in patients wi...

ECGLight: Compute-Light Framework For Paper ECG Digitization and Myocardial Infarction Screening

Electrocardiography (ECG) is one of the most widely used tests for diagnosing cardiovascular disease. Yet several remote clinics still utilize paper E...

Jul 8 2026 2607.07683v1
Heterogeneity of Treatment Effect of Aspirin and Clinically Significant Bleeding in Older Adults

Aim: The global population of older adults is growing, and older age is linked to higher bleeding risk. Although guidelines discourage aspirin for pri...

White Matter Hyperintensity Burden Modifies the Association Between Atrial Fibrillation and Cerebral Microbleeds

Background: In atrial fibrillation (AF), cerebral microbleed (CMB) burden guides anticoagulation decisions, yet AF is itself inconsistently associated...

Biomarker Signal Architecture in Cardiovascular Machine Learning: Stability, Redundancy, and Minimal High-Yield Panels After Myocardial Infarction

Background: Machine-learning models based on circulating biomarkers are increasingly used in cardiovascular research; however, model performance alone...

Systems Pharmacology Reveals Type I Interferon and Myeloid-Like B Cell Reprogramming as Druggable Axes in Antiphospholipid Syndrome

Antiphospholipid syndrome (APS) lacks targeted therapies beyond anticoagulation, and its molecular heterogeneity remains poorly characterized. We empl...

Artificial Intelligence for Cardiac Biomarkers After Myocardial Infarction: A Systematic Review and a Leakage-Aware Modeling Framework

Aims To systematically evaluate how artificial intelligence and machine-learning (AI/ML) methods are applied to cardiac biomarkers after myocardial in...

Non-Invasive Arterial Blood Pressure Waveform Generation in Critically Ill Patients: A Sensor-Based Deep Learning Approach

Continuous monitoring of Arterial Blood Pressure (ABP) in critically ill patients requires invasive arterial catheterization, which carries risks of t...

AI-driven selection of patients with non-valvular atrial fibrillation for oral anticoagulation therapy: a multi-cohort validation and impact evaluation study

Background: Current risk assessment tools for guiding direct oral anticoagulant (DOAC) therapy for patients with atrial fibrillation (AF) based on cli...

Reward-Guided Generation Improves the Scientific Utility of Synthetic Biomedical Data

Synthetic data generation is a promising approach for biomedical data sharing and dataset augmentation, yet existing methods lack mechanisms to preser...

Token Coherence: Adapting MESI Cache Protocols to Minimize Synchronization Overhead in Multi-Agent LLM Systems

Multi-agent LLM orchestration incurs synchronization costs scaling as O(n x S x |D|) in agents, steps, and artifact size under naive broadcast -- a re...

Mar 16 2026 2603.15183v1
Automatic Cardiac Risk Management Classification using large-context Electronic Patients Health Records

To overcome the limitations of manual administrative coding in geriatric Cardiovascular Risk Management, this study introduces an automated classifica...

Mar 10 2026 2603.09685v1
Automated high-throughput fabrication of patient-specific vessel-on-chips enables a generative AI digital twin--Cascade Learner of Thrombosis (CLoT) for personalized thrombosis prediction

We developed an integrated platform combining high-throughput automated biofabrication, systematic patient-derived tissue experiments, and specialized...

Agentic Trial Emulation to Learn Health System-specific Drug Effects At Scale

Objective: Electronic Health Record (EHR)-based trial emulation can support translation of randomized clinical trial (RCT) evidence into practice, yet...

Protocol for a prospective accuracy study on an artificial intelligence-based ultrasound system for gestational age estimation among pregnant women in Ghana, Kenya and South Africa

Background: Risk screening for pre-eclampsia relies on accurate gestational age assessment, but routine access to ultrasound-based gestational dating ...

Systems Biology and Machine Learning Decode an Immunometabolic Signature for Post-Thrombotic Syndrome

Objective: Post-thrombotic syndrome (PTS), a common complication of deep vein thrombosis, lacks objective diagnostic biomarkers and its molecular mech...

ESUS-AI:a machine learning framework to estimate the most likely embolic source in embolic stroke of undetermined source

Background and Purpose Embolic stroke of undetermined source (ESUS) emains a major diagnostic challenge in vascular neurology, as a substantial propor...

Transformer-based structuring of Italian electronic health records with application in cardiac settings

Purpose: Natural Language Processing (NLP) has the potential to extract structured clinical knowledge from unstructured Electronic Health Records (EHR...

GARD: Genomic Data based Drug Repurposing in Head and Neck Cancer with Large Language Model Validation

Background/ObjectivesHead and neck cancer (HNC) represents the seventh most common cancer diagnosis globally, yet current treatments, including surger...

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