Allergy & Immunology

The Presence of Anti-Lactoferrin Antibodies in a Subgroup of Eosinophilic Granulomatosis with Polyangiitis Patients and Their Possible Contribution to Enhancement of Neutrophil Extracellular Trap Formation.

Lactoferrin (Lf) is one of the antigens of antineutrophil cytoplasmic antibodies (ANCA) and functions as an endogenous suppressor of neutrophil extracellular trap (NET) formation. However, the prevalence and pathogenicity of anti-lactoferrin antibodies (aLf) in ANCA-associated vasculitis (AAV) remain unrevealed. This study aimed to examine the significance of aLf in AAV, initially. Sixty-five sera...

A Machine Learning Approach for MicroRNA Precursor Prediction in Retro-transcribing Virus Genomes.

Identification of microRNA (miRNA) precursors has seen increased efforts in recent years. The difficulty in experimental detection of pre-miRNAs increased the usage of computational approaches. Most of these approaches rely on machine learning especially classification. In order to achieve successful classification, many parameters need to be considered such as data quality, choice of classifier s...

Stimulation of PBMC and Monocyte-Derived Macrophages Toll-Like Receptor Activates Innate Immune Pathways in HIV-Infected Patients on Virally Suppressive Combination Antiretroviral Therapy.

In HIV-infected, combination antiretroviral therapy (cART)-treated patients, immune activation and microbial translocation persist and associate with ...

Characterization of T and B cell repertoire diversity in patients with RAG deficiency.

Recombination-activating genes 1 and 2 ( and ) play a critical role in T and B cell development by initiating the recombination process that controls ...

Improving Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) Treatment Monitoring in South Africa: Evaluation of an Advanced TB/HIV Course for Healthcare Workers.

BACKGROUND: South Africa has dual epidemics of human immunodeficiency virus (HIV) and tuberculosis (TB). Nurse-focused training was combined with onsi...

Exposure assessment models for elemental components of particulate matter in an urban environment: A comparison of regression and random forest approaches.

Exposure assessment for elemental components of particulate matter (PM) using land use modeling is a complex problem due to the high spatial and tempo...

Ultrasensitive Protease Sensors Using Selective Affinity Binding, Selective Proteolytic Reaction, and Proximity-Dependent Electrochemical Reaction.

The development of a fast and ultrasensitive protease detection method is a challenging task. This paper reports ultrasensitive protease sensors explo...

Non-ionic iodinated contrast media related immediate reactions: A mechanism study of 27 patients.

The underlying mechanism of non-ionic iodinated contrast media-related immediate reactions was evaluated in this study. Patients presenting at least g...

The Design and Characterization of a Flexible Tactile Sensing Array for Robot Skin.

In this study, a flexible tactile sensing array based on a capacitive mechanism was designed, fabricated, and characterized for sensitive robot skin. ...

Analysis of correlation between pediatric asthma exacerbation and exposure to pollutant mixtures with association rule mining.

OBJECTIVES: Traditional studies on effects of outdoor pollution on asthma have been criticized for questionable statistical validity and inefficacy in...

Automatic detection and classification of leukocytes using convolutional neural networks.

The detection and classification of white blood cells (WBCs, also known as Leukocytes) is a hot issue because of its important applications in disease...

Energy Efficient Monitoring of Metered Dose Inhaler Usage.

Life-long chronic inflammatory diseases of the airways, such as asthma and Chronic Obstructive Pulmonary Disease, are very common worldwide, affecting...

Malaria Parasitemia and Parasite Density in Antiretroviral-Treated HIV-Infected Adults Following Discontinuation of Cotrimoxazole Prophylaxis.

BACKGROUND:  Cotrimoxazole (CTX) discontinuation increases malaria incidence in human immunodeficiency virus (HIV)-infected individuals. Rates, quanti...

MAG-DPA curbs inflammatory biomarkers and pharmacological reactivity in cytokine-triggered hyperresponsive airway models.

Bronchial inflammation contributes to a sustained elevation of airway hyperresponsiveness (AHR) in asthma. Conversely, omega-3 fatty acid derivatives ...

Differential association of plasma monocyte chemoattractant protein-1 with systemic inflammatory and airway remodeling biomarkers in type-2 diabetic patients with and without asthma.

BACKGROUND: Chronic inflammation is a hallmark of type-2 diabetes (T2D) and asthma. Monocyte chemoattractant protein (MCP)-1 or CCL-2 is a key regulat...

Transient Anisocoria during Medial Blowout Fracture Surgery.

Transient anisocoria is rare during blowout fracture reconstruction. We report a case of transient anisocoria occurring during medial blowout fracture...

Machine learning approaches to personalize early prediction of asthma exacerbations.

Patient telemonitoring results in an aggregation of significant amounts of information about patient disease trajectory. However, the potential use of...

Development and characterization of methoxy poly(ethylene oxide)--poly(ε-caprolactone) (PEO--PCL) micelles as vehicles for the solubilization and delivery of tacrolimus.

Tacrolimus is a potent immunosuppressant; however, it suffers from several problems such as poor water solubility (4-12 μg/mL), low and variable oral ...

Feature Extraction and Machine Learning for the Classification of Brazilian Savannah Pollen Grains.

The classification of pollen species and types is an important task in many areas like forensic palynology, archaeological palynology and melissopalyn...

The Ontology for Biomedical Investigations.

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how inv...