Allergy

Explainable machine learning identifies features and thresholds predictive of immunotherapy response.

The identification of reliable predictors for immunotherapy response remains a critical challenge in precision oncology. Here, we integrated patient clinical features with DNA and RNA sequencing data derived from 229 melanoma samples. We use 138 melanoma samples to develop and train machine learning models predicting patient treatment response. Feature selection included a univariate Mann-Whitney ...

Integrative single-cell and bulk transcriptomic analysis identifies lesion-associated gene signatures for prognostic stratification and therapeutic guidance in head and neck squamous cell carcinoma.

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with poor prognosis and variable response to therapy. Effective biomarkers for prognosis and treatment guidance remain limited. METHODS: We performed integrative analysis of single-cell and bulk RNA-seq data to dissect the tumor microenvironment and identify lesion-associated transcriptional changes. Gen...

Microbiome in Gastrointestinal Tumors: Implications in Oncogenesis and Therapeutic Response : Microbiome in Gastrointestinal Tumors.

PURPOSE OF REVIEW: To provide an updated overview of the role of the human microbiome in the initiation, progression, and therapeutic response of gast...

Machine learning prediction of surgical approach and clinical heterogeneity in cervical spondylotic myelopathy.

BACKGROUND: Preoperative planning of the surgical approach for cervical spondylotic myelopathy (CSM) is central to precision medicine. This study used...

ASO Special Article: Proceedings of the Inaugural Joint US-India Cancer Dialogue: Accelerating Collaboration to Advance Cancer Prevention, Early Detection, Treatment, and Care.

BACKGROUND: Cancer is a leading cause of death in both the USA and India. During Prime Minister Narendra Modi's State Visit to Washington, DC in June ...

Pan-cancer analysis of single-cell profiles with polygenic signals reveals genetic influences on tumor immunity across cancers.

Inherited genetic variation can weaken the ability of the immune system to detect and eliminate malignant cells, limiting the effectiveness of cancer ...

Cytokine-induced killer (CIK) Cells-associated transcriptome signature reveals the potential immunomodulatory role of TNFSF14 in clear cell renal cell carcinoma.

Among adoptive immune cell therapies, cytokine-induced killer cell (CIK) therapy has demonstrated clear therapeutic relevance in multiple cancers, par...

PFAS is associated with perineural invasion in triple-negative breast cancer with a potential role for Cathepsin D dysregulation: a multi-omics and experimental study.

Per- and polyfluoroalkyl substances (PFAS) are persistent pollutants linked to breast cancer (BC), but their role in perineural invasion (PNI) of trip...

TFRC-mediated immune exclusion as a therapeutic vulnerability in cervical cancer: A comprehensive analysis based on the cancer immunoediting process.

BACKGROUND: Advanced and recurrent cervical cancer (CC) remains a clinical challenge due to limited therapeutic options and a poor 5-year survival rat...

Prospects and Challenges of Personalized Immunotherapy in Breast Cancer Treatment and Long-term Cancer Management.

Breast cancer is highly heterogeneous,and different molecular subtypes exhibit significant variations in their response to immunotherapy.While signifi...

Unraveling the Multifunctional and Translational Paradigm of Nanoparticulate Systems against Colorectal Cancer.

Colorectal cancer (CRC) is a health burden due to its high mortality rate, recurrence rate, and drug resistance. The limitations of traditional method...

Nanomedicine carrier-based combined antitumor strategy integrating phototherapy and immunotherapy.

INTRODUCTION: The combination of phototherapy (PTT/PDT) and immunotherapy holds promise for cancer treatment but is hindered by poor spatiotemporal co...

Genome-wide variation in cell-free DNA end motif entropy predicts immunotherapy response in head and neck cancer.

BACKGROUND: Minimally invasive biomarkers predicting immunotherapy response in head and neck squamous cell carcinoma (HNSCC) remain an unmet clinical ...

The Role of Inflammatory Biomarkers in Disease Severity and Treatment Response across Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa-A Narrative Review.

Chronic inflammatory skin diseases (CISDs) such as psoriasis (PsO), atopic dermatitis (AD), and hidradenitis suppurativa (HS) involve both cutaneous a...

Development and validation of artificial intelligence-based model for bladder cancer immunophenotyping using whole slide images.

The classification of immunophenotypes in muscle-invasive bladder cancer (MIBC) is critical for predicting immunotherapy response and clinical outcome...

Synthetic Inducible Bacteria Normalize the Microenvironment of Refractory Tumors, Potentiating Checkpoint Inhibitor Responses.

Immunotherapy has transformed cancer treatment but remains ineffective in many solid tumors, largely due to the immunosuppressive tumor microenvironme...

Clinical outcomes and predictors of response to PD-(L)1 blockade in patients with NSCLC without actionable genomic alterations who never used tobacco.

PURPOSE: Predictive biomarkers of response to immune checkpoint inhibitors (ICI) remain poorly defined in patients with non-small cell lung cancer (NS...

Calcite nanoparticles as advanced, pH-responsive platforms for cancer therapy: a comprehensive and critical review.

Nanomedicine offers powerful opportunities to overcome the pharmacokinetic and microenvironmental limitations of conventional chemotherapy, particular...

Cytokines and immunologic checkpoint molecules in predicting success of allergen immunotherapy.

There are large variations in how individual patients respond to allergen immunotherapy (AIT) against grass and/or birch allergy. There are currently ...

Predictors of the Efficacy of Focused Ultrasound for Moderate-to-Severe Persistent Allergic Rhinitis: A Retrospective Cohort Study.

BACKGROUND: Focused ultrasound (FUS) has achieved favorable results in the treatment of allergic rhinitis (AR). However, some patients still have poor...