Allergy

Disulfide bond-related gene signature development for bladder cancer prognosis prediction and immune microenvironment characterization.

Bladder cancer is the fourth most common malignant tumor in men, with limited therapeutic biomarkers and heterogeneous responses to immunotherapy. Disulfide bond-driven cell death has emerged as a critical regulator of tumor progression and immune microenvironment remodeling. By integrating data from TCGA and GEO cohorts, we developed a Disulfide-Related Prognostic Signature (DRPS) using ten machi...

CT-Based Radiomics for Predicting PD-L1 Expression in Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis.

BACKGROUND AND PURPOSE: The efficacy of immunotherapy in non-small cell lung cancer (NSCLC) is intricately associated with baseline PD-L1 expression rates. The standard method for measuring PD-L1 is immunohistochemistry, which is invasive and may not capture tumor heterogeneity. The primary aim of the current study is to assess whether CT-based radiomics models can accurately predict PD-L1 express...

The Integration of Artificial Intelligence Into Precision Medicine for Neuro-Oncology: Ethical, Clinical, and Nursing Implications in Immunotherapy Care.

This paper explores how artificial intelligence (AI) is being woven into precision medicine for neuro-oncology, highlighting its ethical, clinical, an...

Comparative Evaluation of ChatGPT and ChatGLM Performance in Response to Common Queries on Pediatric Atopic Dermatitis.

BACKGROUND: Atopic dermatitis (AD) is a prevalent chronic and recurrent skin condition in children. Developing novel and standardized management strat...

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer.

The tumor microenvironment (TME) significantly influences cancer prognosis and therapeutic outcomes, yet its composition remains highly heterogeneous,...

Biophysical modeling for accurate T cell specificity prediction of viral and tumor antigens.

Accurate predictions of T cell receptor (TCR) specificity remain an important open problem in immunology, with broad implications for vaccine design, ...

Unbiased Quantification of Persistent Postural and Motor Deficits Following Spinal Cord Injury in Mice.

Spinal cord injury (SCI) causes multifaceted postural and motor impairments that are challenging to quantify. Conventional behavioral tests, such as t...

High Throughput Meta-analysis of Antimicrobial Peptides for Characterizing Class Specific Therapeutic Candidates: An In Silico Approach.

The increasing incidence of antimicrobial resistance is becoming a serious concern worldwide and requires newer drugs. Recent evidence has shown growi...

[Current status and trends of perioperative immunotherapy for gastric cancer].

In recent years,immunotherapy,particularly immune checkpoint inhibitors,has been widely used in the treatment of both solid and non-solid tumors,and i...

Baseline Radiomics as a Prognostic Tool for Clinical Benefit from Immune Checkpoint Inhibition in Inoperable NSCLC Without Activating Mutations.

Checkpoint inhibitors (ICIs) are key therapies for NSCLC, but current selection criteria, such as excluding mutation carriers and assessing PD-L1, la...

Multi-Omics Analysis of the virulence factors and designing of next-generation multi-epitopes Vaccines against Rickettsia prowazekii: a computer-aided vaccine designing approach.

Rickettsia is a genus of bacteria that are obligate intracellular parasites and are responsible for the febrile diseases known collectively as Rickett...

High-fidelity in silico generation and augmentation of TCR repertoire data using generative adversarial networks.

Engineered T-cell receptor (eTCR) systems rely on accurately generated T-cell receptor (TCR) sequences to enhance immunotherapy predictability and eff...

Construction and Multi-dimensional Validation of a Lactylation-Related Signature for Glioblastoma Multiforme Prognostic and Therapeutic Purposes.

Glioblastoma multiforme, one of the most malignant types of brain tumor, heavily relies on glycolytic pathways and is significantly influenced by immu...

Single-cell multimodal analysis reveals tumor microenvironment predictive of treatment response in non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) constitutes over 80% of lung cancer cases and remains a leading cause of cancer-related mortality worldwide. Despit...

Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.

Despite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the therapeutic benefit of direct STING agonists appe...

Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer.

INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predomin...

Immunopeptidomics-guided discovery and characterization of neoantigens for personalized cancer immunotherapy.

Neoantigens have emerged as ideal targets for personalized cancer immunotherapy. We depict the pan-cancer peptide atlas by comprehensively collecting ...

A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway.

Wnt signaling is important in embryonic development and tumorigenesis. These biological effects can be exerted by the activation of the β-catenin-depe...

Assessing the generalization capabilities of TCR binding predictors via peptide distance analysis.

Understanding the interaction between T Cell Receptors (TCRs) and peptide-bound Major Histocompatibility Complexes (pMHCs) is crucial for comprehendin...

Impact of ITH on PRAD patients and feasibility analysis of the positive correlation gene MYLK2 applied to PRAD treatment.

INTRODUCTION: Prostate adenocarcinoma (PRAD) is an extremely widespread site of urological malignancy and is the second most common male cancer in the...