Allergy & Immunology

Allergy

Latest AI and machine learning research in allergy for healthcare professionals.

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Allergy-Immunology Subcategories: Allergy
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When AI Shows Its Work, Is It Actually Working? Step-Level Evaluation Reveals Frontier Language Models Frequently Bypass Their Own Reasoning

Language models increasingly "show their work" by writing step-by-step reasoning before answering. B...

Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis

Regional lymph node (LN) metastasis critically influences distant metastatic progression, anti-tumou...

Rational Design of Selective IL-2-based Activators for CAR T Cells Using AlphaFold3 and Physics-Informed Machine Learning

Recombinant human Interleukin-2 (rhIL-2, Aldesleukin) is used in immunotherapy for metastatic melano...

Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman Spectroscopy and AI

Identifying predictive biomarkers of immunotherapeutic response in melanoma remains an outstanding c...

SwiftTCR: Efficient Computational Docking protocol of TCRpMHC-I Complexes Using Restricted Rotation Matrices

The T cell's ability to discern self and non-self depends on its T cell receptor (TCR), which recogn...

A spatial multi-omic portrait of survival outcome for clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is the leading cause of kidney cancer-related death, but how...

Modeling Microbiome Modulation of Tumor Metabolic Networks to Predict Synergistic Therapies

Differences in microbiome composition profoundly influence drug response, yet methods to model the m...

Structure-Based TCR-pMHC Binding Prediction and Generalization to Unseen Peptides

The interaction between T-cell receptors (TCRs) with the peptide-bound major histocompatibility comp...

Generative AI Guided Design of High-Affinity T cell Receptors

Developing T cell receptors (TCRs) with sufficiently high affinity for tumor antigens (TAs) remains ...

Pathwise Test-Time Correction for Autoregressive Long Video Generation

Distilled autoregressive diffusion models facilitate real-time short video synthesis but suffer from...

Selective Glucocorticoid Receptor Modulators of Immune Checkpoint Function

Glucocorticoids (GCs) coordinate immunity, inflammation and metabolism through allosteric regulation...

Ophiuchus-Ab: A Versatile Generative Foundation Model for Advanced Antibody-Based Immunotherapy

Antibodies exhibit extraordinary specificity and diversity in antigen recognition and have become a ...

Data Augmentation for High-Fidelity Generation of CAR-T/NK Immunological Synapse Images

Chimeric antigen receptor (CAR)-T and NK cell immunotherapies have transformed cancer treatment, and...

AI quantification of inflammatory and architectural features in ulcerative colitis distinguishes active disease from remission

Background and Aims: Artificial intelligence (AI) is increasingly applied to histological assessment...

Structure-constrained Language-informed Diffusion Model for Unpaired Low-dose Computed Tomography Angiography Reconstruction

The application of iodinated contrast media (ICM) improves the sensitivity and specificity of comput...

TCRAD: An End-to-End Framework for Antigen-Targeted T Cell Receptor Design

Understanding and engineering T-cell receptor (TCR) specificity is central to personalized immunothe...

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