Arthritis

The research progress of biologics in elderly-onset rheumatoid arthritis (EORA).

is a distinct subtype of characterized by heightened treatment challenges due to immune aging and the complexity of comorbidities. This review systematically summarizes the definition, clinical features, epidemiological trends, therapeutic challenges, and the potential applications of biologic agents in . It primarily focuses on the efficacy, safety, and individualized treatment strategies assoc...

Association of and gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population.

INTRODUCTION: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II, nevertheless some HLA class I associations have also been observed. These molecules present antigenic peptides to CD8+ T lymphocytes and natural killer cells. HLA-I molecules bind their peptide cargo (8-10 amino acids long) in the endoplasmi...

A practical guide to FAIR data management in the age of multi-OMICS and AI.

Multi-cellular biological systems, including the immune system, are highly complex, dynamic, and adaptable. Systems biologists aim to understand such ...

LMSST-GCN: Longitudinal MRI sub-structural texture guided graph convolution network for improved progression prediction of knee osteoarthritis.

BACKGROUND AND OBJECTIVES: Accurate prediction of progression in knee osteoarthritis (KOA) is significant for early personalized intervention. Previou...

Identification of biomarkers for knee osteoarthritis through clinical data and machine learning models.

Knee osteoarthritis (KOA) represents a progressive degenerative disorder characterized by the gradual erosion of articular cartilage. This study aimed...

Visualizing Preosteoarthritis: Updates on UTE-Based Compositional MRI and Deep Learning Algorithms.

Osteoarthritis (OA) is heterogeneous and involves structural changes in the whole joint, such as cartilage, meniscus/labrum, ligaments, and tendons, m...

Machine learning-based prediction model integrating ultrasound scores and clinical features for the progression to rheumatoid arthritis in patients with undifferentiated arthritis.

OBJECTIVES: Predicting rheumatoid arthritis (RA) progression in undifferentiated arthritis (UA) patients remains a challenge. Traditional approaches c...

Deciphering hub genes and immune landscapes related to neutrophil extracellular traps in rheumatoid arthritis: insights from integrated bioinformatics analyses and experiments.

BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and progressive joint destruction. Neutro...

Exploring the shared gene signatures and mechanism among three autoimmune diseases by bulk RNA sequencing integrated with single-cell RNA sequencing analysis.

BACKGROUND: Emerging evidence underscores the comorbidity mechanisms among autoimmune diseases (AIDs), with innovative technologies such as single-cel...

Development and validation of a new nomogram for self-reported OA based on machine learning: a cross-sectional study.

Developing a new diagnostic prediction model for osteoarthritis (OA) to assess the likelihood of individuals developing OA is crucial for the timely i...

Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing.

BACKGROUND: Anti-citrullinated peptide antibodies (ACPA)-negative (ACPA-) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic ch...

Enhancing patient education on the role of tibial osteotomy in the management of knee osteoarthritis using a customized ChatGPT: a readability and quality assessment.

INTRODUCTION: Knee osteoarthritis (OA) significantly impacts the quality of life of those afflicted, with many patients eventually requiring surgical ...

OA-MEN: a fusion deep learning approach for enhanced accuracy in knee osteoarthritis detection and classification using X-Ray imaging.

BACKGROUND: Knee osteoarthritis (KOA) constitutes the prevailing manifestation of arthritis. Radiographs function as a common modality for primary scr...

Artificial intelligence-based cardiovascular/stroke risk stratification in women affected by autoimmune disorders: a narrative survey.

Women are disproportionately affected by chronic autoimmune diseases (AD) like systemic lupus erythematosus (SLE), scleroderma, rheumatoid arthritis (...

Predicting rapid progression in knee osteoarthritis: a novel and interpretable automated machine learning approach, with specific focus on young patients and early disease.

OBJECTIVES: To facilitate the stratification of patients with osteoarthritis (OA) for new treatment development and clinical trial recruitment, we cre...

Knee osteoarthritis severity detection using deep inception transfer learning.

Osteoarthritis (OA) is a prevalent condition resulting in physical limitations. Early detection of OA is critical to effectively manage this condition...

Harnessing the Power of Machine Learning Guided Discovery of NLRP3 Inhibitors Towards the Effective Treatment of Rheumatoid Arthritis.

The NLRP3 inflammasome, plays a critical role in the pathogenesis of rheumatoid arthritis (RA) by activating inflammatory cytokines such as IL1β and I...

Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: .

BACKGROUND: Psoriasis represents a persistent, immune-driven inflammatory condition affecting the skin, characterized by a lack of well-established bi...

Robotic-assisted versus conventional hip arthroplasty: a comparative analysis of perioperative blood management and early outcomes.

PURPOSE: This study aimed to evaluate the impact of Robotic-Assisted Total Hip Arthroplasty (RATHA) versus Conventional Total Hip Arthroplasty (CTHA) ...

Mapping two decades of research in rheumatology-specific journals: a topic modeling analysis with BERTopic.

BACKGROUND: Rheumatology has experienced notable changes in the last decades. New drugs, including biologic agents and Janus kinase (JAK) inhibitors, ...