Atherosclerosis

Street view-based exposure to greenspace and mortality: the Multi-Ethnic Study of Atherosclerosis.

Higher exposure to greenspace has been associated with reduced mortality rates in predominantly White samples. However, the specific contribution of different types of greenspace exposures to these associations and whether the associations vary by race and ethnicity have not been studied. Our main objective was to quantify the association between specific types of greenspaces and all-cause mortali...

Multi-omics analysis identifies CD48 and ITIH5 as potential diagnostic biomarkers and therapeutic targets for metabolic disorders associated with obesity.

BACKGROUND: Obesity-driven metabolic disorders involve pathological remodeling of white adipose tissue (WAT), wherein fibroblasts coordinate fibrosis and inflammation. This study aimed to characterize fibroblast transcriptional heterogeneity, identify fibrosis-inflammation mediators, and discover diagnostic and therapeutic targets. METHODS: Single-cell (GSE155960) and bulk (GSE205668) RNA-seq data...

VAV3 is associated with atherosclerosis and ox-LDL-induced endothelial dysfunctional remodeling.

BACKGROUND: Atherosclerosis is a major cause of ischemic stroke and is characterized by complex immune-metabolic dysregulation. VAV3, a Rho guanine nu...

Diagnostic performance of machine learning models versus established risk stratification for intracranial aneurysm rupture: a systematic review and bivariate meta-analysis.

BACKGROUND: Machine learning (ML) models have been proposed to improve the discrimination of intracranial aneurysm rupture status beyond established c...

A Synthetic Data-Augmented Deep Learning Framework for Robust Segmentation and Quantification of the Carotid Artery in Ultrasound Images.

OBJECTIVE: To address the severe limitation imposed by the scarcity of annotated data on deep learning-based automated segmentation of the carotid art...

Fluorescence spectroscopy and machine learning methods for detection of Alzheimer's disease from circulating white blood cells.

BackgroundAlzheimer's disease (AD) is the most common cause of dementia whose prevalence is projected to increase significantly in the coming decades....

Study Design Differences and Temporal Morphology Bias in Intracranial Aneurysm Rupture Research: Toward Prospectively Validated Risk Models: An Umbrella Review.

BACKGROUND AND OBJECTIVE: Risk stratification for unruptured intracranial aneurysms largely relies on meta-analyses that synthesize heterogeneous prim...

Integration of single-cell and bulk RNA sequencing reveals programmed cell death-associated transcriptional programs in sepsis-induced acute lung injury.

BACKGROUND: Sepsis-induced acute lung injury (ALI) is a frequent and life-threatening complication of sepsis, yet clinically actionable transcriptomic...

Endothelial activation and stress index associated with in-hospital mortality risk in patients with end-stage renal disease: a retrospective analysis based on the MIMIC database and machine learning model development.

BACKGROUND: End-stage renal disease (ESRD) is a severe chronic renal disorder with high mortality, requiring dialysis treatment or kidney transplantat...

Translating lineage-resolved single-cell programs to bulk clinical prognosis: Adversarial generative learning reveals lineage-informed immune - stromal - epithelial risk signatures.

BACKGROUND: Breast cancer transcriptional programs span malignant epithelial cells, and the tumor microenvironment (TME), yet tumor-normal contrasts a...

Associations of serum per- and polyfluoroalkyl substances (PFAS) mixture with the risk of chronic diseases: evidence from single‑ , multi-pollutant, and machine learning models.

Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals commonly found in consumer products. Despite growing concern over their health eff...

Unraveling 'F' factor: towards a genetic-clinical framework for the musculoskeletal-heart crosstalk in metabolic aging.

BACKGROUND: The rising co-occurrence of cardiometabolic diseases and musculoskeletal degeneration poses a critical challenge to healthy aging, yet the...

Development and temporal external validation of a high-specificity XGBoost rule-in model for diabetes in middle-aged and older Korean adults.

Early identification of diabetes in older adults is essential for preventing complications, yet many high‑risk individuals remain undetected in commun...

Exploring the potential targets and mechanisms of artemisinin in the treatment of diabetic kidney disease using network pharmacology and molecular docking.

Diabetic kidney disease (DKD) is a secondary glomerular disease caused by diabetes, and its incidence is increasing annually. Artemisinin is an organi...

Integrative multi-omics analysis identifies a circadian rhythm-associated gene signature for prognosis and therapeutic stratification in lung adenocarcinoma.

BACKGROUND/OBJECTIVES: Circadian rhythm disruption is increasingly implicated in tumor progression and therapy resistance. However, its prognostic val...

Exploring the Lung-Liver Axis in Pulmonary Arterial Hypertension.

The liver's contribution to pulmonary arterial hypertension (PAH) pathogenesis remains unclear. We hypothesized that the liver promotes inflammatory i...

Screening and comprehensive analysis of endoplasmic reticulum stress-related biomarkers in atherosclerosis.

Atherosclerosis (AS) is a chronic inflammatory vascular disorder in which endoplasmic reticulum stress (ERS) plays a crucial regulatory role. However,...

Deep learning-based CT-derived vertebral bone mineral density and metformin therapy: a longitudinal study in the Multi-Ethnic Study of Atherosclerosis.

OBJECTIVE: Evidence on metformin's skeletal effects remains conflicting. We emulated a target trial to evaluate associations between metformin therapy...

Gut microbial alterations and functional shifts in patients with hypertriglyceridemia: insights from a northwestern Chinese metagenomic study.

Although hypertriglyceridemia (HTG) is a significant contributor to lipid-associated pathologies such as atherosclerotic cardiovascular disease, its r...

A Multidimensional Integrated Strategy for Identifying Anti-thrombotic Quality Markers(Q-Markers) in Taohong Siwu Decoction through Combined Analysis of Chemical Profiling, Bioactivity, and Pharmacodynamic Efficacy.

ETHNOPHARMACOLOGICAL RELEVANCE: Taohong Siwu Decoction (TSD), originating from the Qing Dynasty medical text Gynecology Ice Mirror, is a representativ...