Chemotherapy

Structural characterization and osteogenic bioactivity of a sulfated polysaccharide from pacific abalone (Haliotis discus hannai Ino).

Bone morphogenic protein-2 (BMP-2) is known to promote osteogenesis. To find novel adjuvants to enhance the activity of BMP-2, the present study investigated the structure BMP-2-induced osteogenic activity of a water-soluble polysaccharide from the gonad of pacific abalone (Haliotis discus hannai Ino) named AGSP. Through analysis of aldobiouronic acids released from AGSP, monosaccharide compositio...

Accuracy of glomerular filtration rate estimationequations in patients with hematopathy.

Renal dysfunction is a common side-effect of chemotherapeuticagents in patients with hematopathy. Although broadly used, glomerularfiltration rate (GFR) estimation equations were not fully validatedin this special population. Thus, this study was designed to furtherassess the accuracy of various GFR equations, including the newly2012 CKD-EPI equations. Referring to Tc-DTPA clearance method, three ...

Stability of azasetron-dexamethasone mixture for chemotherapy-induced nausea and vomiting administration.

Combination antiemetic therapy has become common practice for the prevention of nausea and vomiting caused by anticancer drugs. In this study, we inve...

Effects of Fluorosurfactant Structure and Concentration on Drug Availability and Biocompatibility in Water-in-Perfluorocarbon Emulsions for Pulmonary Drug Delivery.

The efficacy of inhaled antibiotics is often impaired by insufficient drug penetration into plugged and poorly ventilated airways. Liquid ventilation ...

Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like pathway.

This study investigated a lycopene-rich extract from red guava (LEG) for its chemical composition using spectrophotometry, mass spectrometry, attenuat...

Synthesis of poly(1,2-glycerol carbonate)-paclitaxel conjugates and their utility as a single high-dose replacement for multi-dose treatment regimens in peritoneal cancer.

Current chemotherapeutic dosing strategies are limited by the toxicity of anticancer agents and therefore rely on multiple low-dose administrations. A...

Extended Adjuvant Aromatase Inhibitor Therapy in Post-Menopausal Women.

PURPOSE OF THE REVIEW: To understand the evidence for extending adjuvant aromatase inhibitor (AI) therapy from 5 to 10 years in post-menopausal women ...

Validation of a Machine Learning Approach for Venous Thromboembolism Risk Prediction in Oncology.

Using kernel machine learning (ML) and random optimization (RO) techniques, we recently developed a set of venous thromboembolism (VTE) risk predictor...

Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition, cytotoxicity, inflammation and lung fibrosis.

Environmental exposure and health risk upon engineered nanomaterials are increasingly concerned. The family of mesoporous carbon nanomaterials (MCNs) ...

Exploration of Wedelia chinensis leaf-assisted silver nanoparticles for antioxidant, antibacterial and in vitro cytotoxic applications.

Green synthetic route of silver nanoparticles (AgNPs) has already been proved to be an advantageous over other physico-chemical approaches due to its ...

Strategy of metal iron doping and green-mediated ZnO nanoparticles: dissolubility, antibacterial and cytotoxic traits.

Undoped and Fe-doped ZnO nanoparticles (NPs) were synthesized using leaf extract as a reducing agent. The physicochemical traits, dissolution, cytoto...

Comparing the Effect of Adding Fentanyl, Sufentanil, and Placebo with Intrathecal Bupivacaine on Duration of Analgesia and Complications of Spinal Anesthesia in Patients Undergoing Cesarean Section.

BACKGROUND: Spinal anesthesia is the method of choice for most elective and emergency Cesarean sections. To increase the duration of anesthesia and im...

Bladder Cancer Treatment Response Assessment in CT using Radiomics with Deep-Learning.

Cross-sectional X-ray imaging has become the standard for staging most solid organ malignancies. However, for some malignancies such as urinary bladde...

Reinforcement learning-based control of drug dosing for cancer chemotherapy treatment.

The increasing threat of cancer to human life and the improvement in survival rate of this disease due to effective treatment has promoted research in...

Tramadol sparing effect of dexmedetomidine as an adjuvant with lignocaine in preoperative stellate ganglion block for postoperative pain relief following upper limb surgeries.

BACKGROUND: Recent literature has established the role of stellate ganglion block (SGB) for management of acute postoperative pain. The effects of dex...

Effects of Oleo Gum Resin of L. on Senescence in Human Dermal Fibroblasts: - Asafoetida reverses senescence in fibroblasts.

OBJECTIVES: Based on data from Chinese and Indian traditional herbal medicines, gum resin of (sometimes referred to asafetida or asafoetida) has seve...

Biological activities of plant extracts from and : An antimalarial, antitrypanosomal and cytotoxity evaluation.

The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated. Wood of Roxb. e...

Synthesis and Biological Evaluations of Ring Substituted Tetrahydroisoquinolines (THIQs) as Anti-Breast Cancer Agents.

Breast cancer is a leading cause of mortality among women, resulting in more than half a million deaths worldwide every year. Although chemotherapeuti...

A Novel Case of Somatic Mutation in Pediatric-Onset Aldosterone-Producing Adenoma.

Aldosterone-producing adenoma (APA), a subtype of primary aldosteronism, is a common cause of secondary hypertension in adults. Somatic mutations hav...

Mesenteric approach during pancreaticoduodenectomy for pancreatic ductal adenocarcinoma.

Mesenteric approach is an artery-first approach during pancreaticoduodenectomy (PD). In the present study, we evaluated clinical and oncological benef...