Clinical Trials

Effects of aged garlic extract on arterial elasticity in a placebo-controlled clinical trial using EndoPAT™ technology.

Cardiovascular diseases are the main cause of death in the industrialized world, with the main risk factors being elevated blood pressure and blood lipid levels, leading to arterial stiffness and arteriosclerosis. In this study, we examined the effect of aged garlic extract (AGE) on arterial elasticity, using the EndoPAT™ technology in subjects with slightly elevated blood pressure. This randomize...

Beyond Performance Metrics: Automatic Deep Learning Retinal OCT Analysis Reproduces Clinical Trial Outcome.

PURPOSE: To validate the efficacy of a fully automatic, deep learning-based segmentation algorithm beyond conventional performance metrics by measuring the primary outcome of a clinical trial for macular telangiectasia type 2 (MacTel2).

Land-walking vs. water-walking interventions in older adults: Effects on aerobic fitness.

BACKGROUND: Low cardiorespiratory fitness is an independent predictor of all-cause and cardiovascular mortality, and interventions that increase fitne...

Estimating individualized treatment regimes from crossover designs.

The field of precision medicine aims to tailor treatment based on patient-specific factors in a reproducible way. To this end, estimating an optimal i...

Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock - rationale and design of a multicenter randomized controlled superiority trial.

BACKGROUND: Antibiotic exposure is often inadequate in critically ill patients with severe sepsis or septic shock and this is associated with worse ou...

Ultrasound-Guided Subclavian Perivascular Brachial Plexus Block Using 0.5% Bupivacaine with Dexmedetomidine as an Adjuvant: A Prospective Randomized Controlled Trial.

BACKGROUND: Ultrasound guidance has dramatically improved the accuracy of nerve localization, and various adjuvants prolong the block and extend analg...

Comparison of Continuous Wound Infusion versus Continuous Epidural Infusion in Upper Abdominal Surgery: Noninferiority Randomized Controlled Trial.

CONTEXT: Wound catheter offers a less invasive alternative for postoperative analgesia in the abdominal surgery.

Pharmacokinetic-pharmacodynamic assessment of the ivermectin and abamectin nematodicidal interaction in cattle.

In a context of nematodicidal resistance, anthelmintic combinations have emerged as a reliable pharmacological strategy to control gastrointestinal ne...

Out damn bot, out: Recruiting real people into substance use studies on the internet.

While the Internet has become a popular and effective strategy for recruiting substance users into research, there is a large risk of recruiting dupli...

Cell proliferation activity delineated by molecular docking of four new compounds isolated from the aerial parts of Forssk. ex. J.F. Gmel.

Using different chromatographic methods, four new compounds were isolated from the aerial parts of (Chenopodiaceae) along with 2-hydroxy-1-naphthoic ...

Immunogenicity and safety of a 12-valent pneumococcal conjugate vaccine in infants aged 6-10 weeks: a randomized double-blind active-controlled trial.

BACKGROUND: Pneumococcal diseases among children aged <5 years worldwide are associated with high annual mortality rates.

The influence of on rumen morphometrics of cull cows immediately stepped up to a high-energy finishing diet.

Forty-five beef cull cows [body weight () = 503 ± 58 kg; body condition score () = 2.1 ± 0.6] were randomized into two treatments to compare the effec...

Effectiveness of Intervention Based on End-effector Gait Trainer in Older Patients With Stroke: A Systematic Review.

OBJECTIVE: The objective of the article is to analyze the effects of the end-effector technology for gait rehabilitation on acute, subacute, and chron...

Autologous fat graft assisted by stromal vascular fraction improves facial skin quality: A randomized controlled trial.

BACKGROUND: Cell-assisted lipotransfer (CAL) promotes the survival of fat grafts with high vascular density and improves skin quality by increasing co...

Protocol for the Effectiveness of an Anesthesiology Control Tower System in Improving Perioperative Quality Metrics and Clinical Outcomes: the TECTONICS randomized, pragmatic trial.

Perioperative morbidity is a public health priority, and surgical volume is increasing rapidly. With advances in technology, there is an opportunity ...

Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines.

In the twenty-first century, high contagious infectious diseases such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndr...

Is There a Role for Preoperative Local Infiltration of Tranexamic Acid in Elective Spine Surgery? A Prospective Randomized Controlled Trial Analyzing the Efficacy of Intravenous, Local Infiltration, and Topical Administration of Tranexamic Acid.

STUDY DESIGN: Randomized control trial.

Psychiatry and Fitness to Fly After Germanwings.

In March 2015, a co-pilot flying Germanwings Flight 9525 deliberately pointed his airplane into a descent, killing himself, five other crew members, a...

Randomized Phase II Trial of Exercise, Metformin, or Both on Metabolic Biomarkers in Colorectal and Breast Cancer Survivors.

BACKGROUND: Observational data support inverse relationships between exercise or metformin use and disease outcomes in colorectal and breast cancer su...

Safety and efficacy of Belfeed B MP/ML (endo-1,4-β-xylanase) as a feed additive for sows, in order to have benefits in piglets, and for all porcine species.

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver ...