Clinical Trials

A prospective, randomized, blinded-endpoint, controlled study - continuous epidural infusion versus programmed intermittent epidural bolus in labor analgesia.

BACKGROUND: There is evidence that administration of a programmed intermittent epidural bolus (PIEB) compared to continuous epidural infusion (CEI) leads to greater analgesia efficacy and maternal satisfaction with decreased anesthetic interventions.

Intraoperative monitoring of stroke volume variation versus central venous pressure in laparoscopic liver surgery: a randomized prospective comparative trial.

BACKGROUND: Central venous pressure (CVP) is used as a marker of cardiac preload to control intraoperative blood loss in open hepatectomies, while its reliability in laparoscopy is less certain. The aim of this randomized prospective trial was to evaluate the outcome of laparoscopic resections performed with stroke volume variation (SVV) or CVP monitoring.

Comparison of emergence after deep extubation using desflurane or desflurane with remifentanil in patients undergoing general anesthesia: a randomized trial.

STUDY OBJECTIVE: To compare recovery times and respiratory complications during emergence after deep extubation using either desflurane alone or a low...

Coherent and intermittent ensemble oscillations emerge from networks of irregular spiking neurons.

Local field potential (LFP) recordings from spatially distant cortical circuits reveal episodes of coherent gamma oscillations that are intermittent, ...

Prediction the Substrate Specificities of Membrane Transport Proteins Based on Support Vector Machine and Hybrid Features.

Membrane transport proteins and their substrate specificities play crucial roles in a variety of cellular functions. Identifying the substrate specifi...

Extremely Randomized Machine Learning Methods for Compound Activity Prediction.

Speed, a relatively low requirement for computational resources and high effectiveness of the evaluation of the bioactivity of compounds have caused a...

Effects of combining robot-assisted therapy with neuromuscular electrical stimulation on motor impairment, motor and daily function, and quality of life in patients with chronic stroke: a double-blinded randomized controlled trial.

BACKGROUND: Robot-assisted therapy (RT) is a widely used intervention approach to enhance motor recovery in patients after stroke, but its effects on ...

Novel biopreservatives to enhance the safety and quality of strawberry juice.

Pomegranate extract, vanillin and geraniol were studied as natural antimicrobials on strawberry juice. Strawberry juice was treated with each agent at...

Aggressive hydraTion in patients with ST-Elevation Myocardial infarction undergoing Primary percutaneous coronary intervention to prevenT contrast-induced nephropathy (ATTEMPT): Study design and protocol for the randomized, controlled trial, the ATTEMPT, RESCIND 1 (First study for REduction of contraSt-induCed nephropathy followINg carDiac catheterization) trial.

Adequate hydration is recommended for acute ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention ...

Long-range recruitment of Martinotti cells causes surround suppression and promotes saliency in an attractor network model.

Although the importance of long-range connections for cortical information processing has been acknowledged for a long time, most studies focused on t...

Antimicrobial efficacy of the EndoVac system plus PDT against intracanal Candida albicans: an ex vivo study.

This study evaluated the ex vivoantimicrobial efficacy of the EndoVac system and the photodynamic therapy (PDT) associated with chemomechanical debrid...

Long-term Effectiveness of Intensive Therapy in Chronic Stroke.

Background While recent clinical trials involving robot-assisted therapy have failed to show clinically significant improvement versus conventional th...

A Tool for Predicting Regulatory Approval After Phase II Testing of New Oncology Compounds.

We developed an algorithm (ANDI) for predicting regulatory marketing approval for new cancer drugs after phase II testing has been conducted, with the...

Machine-Learning-Based Analysis in Genome-Edited Cells Reveals the Efficiency of Clathrin-Mediated Endocytosis.

Cells internalize various molecules through clathrin-mediated endocytosis (CME). Previous live-cell imaging studies suggested that CME is inefficient,...

Transurethral versus suprapubic catheter at robot-assisted radical prostatectomy: a prospective randomized trial with 1-year follow-up.

OBJECTIVE: To evaluate urethral catheter (UC) versus suprapubic tube (SPT) without stenting the anastomosis at robot-assisted radical prostatectomy (R...

How to build up the actionable knowledge base: the role of 'best fit' framework synthesis for studies of improvement in healthcare.

Increasing recognition of the role and value of theory in improvement work in healthcare offers the prospect of capitalising upon, and consolidating, ...

Pharmacokinetics of aclidinium bromide/formoterol fumarate fixed-dose combination compared with individual components: A phase 1, open-label, single-dose study.

Inhaled, long-acting bronchodilators represent a cornerstone of maintenance treatment for chronic obstructive pulmonary disease (COPD). Aclidinium bro...

Effects of a wearable exoskeleton stride management assist system (SMA®) on spatiotemporal gait characteristics in individuals after stroke: a randomized controlled trial.

BACKGROUND: Robots offer an alternative, potentially advantageous method of providing repetitive, high-dosage, and high-intensity training to address ...

Robot-assisted primary cementless total hip arthroplasty with a short femoral stem: a prospective randomized short-term outcome study.

BACKGROUND: Recently, two topical issues in total hip arthroplasty (THA) have been robot-assisted surgery and use of a short stem. The purpose of this...

Risk assessment of supply chain for pharmaceutical excipients with AHP-fuzzy comprehensive evaluation.

As the essential components in formulations, pharmaceutical excipients directly affect the safety, efficacy, and stability of drugs. Recently, safety ...