Public Health & Policy

Clinical Trials

Latest AI and machine learning research in clinical trials for healthcare professionals.

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Quality of Clinical Notes Created by Ambient Listening Generative AI: Pragmatic Prospective Pilot Study.

BACKGROUND: Physicians routinely document specifics of patient encounters in clinic visit notes, a critical but potentially time-consuming task. Ambient listening artificial intelligence (AI) technology is being integrated into clinical workflows to reduce documentation burden by creating draft visit notes. While this technology is promising, it is not perfect, and the potential for patient harm n...

Apr 17 2026 41996389

Screening of molecular signatures from microRNA and mRNA expression profiling related to the efficacy of the antidepressant duloxetine and analysis of their regulatory relationship.

Previous clinical studies have reported that not all depressed patients respond to antidepressants. Therefore, finding potential predictive molecular biomarkers is crucial for providing important guidelines in the diagnosis and treatment of depression. In recent years, some studies have identified potential signature molecules using machine learning analysis of transcriptomic data. In this study, ...

Apr 16 2026 41997083
The Insomnia EEG Score: a new tool for the classification of people with poor sleep.

Quantitative features could help objectively identify and grade insomnia severity, though there is currently no pathophysiological biomarker of insomn...

Apr 16 2026 41217192
Natural bioactive as modulators of airway inflammation and remodeling: mechanistic insights.

Airway diseases such as asthma, COPD, pulmonary fibrosis, and other inflammatory airway conditions remain a significant threat to global health. Tradi...

Apr 15 2026 42004167
The nonlinear impact of road safety policy implementation on the severity of road traffic crashes: A fusion of deep learning and Bayesian random parameter methods.

Road crashes remain a primary focus in the field of traffic safety research due to their potentially severe societal and individual consequences. Whil...

Apr 15 2026 41990541
Update on pleural mesothelioma.

PURPOSE OF REVIEW: Pleural mesothelioma remains a universally lethal cancer with a rising global burden. This underscores the need for pulmonologists ...

Apr 15 2026 41982104
MRI-Guided High-Intensity Focused Ultrasound in Movement Disorders: Targeting Pathologic Brain Circuits With Precision Imaging, From the AJR Special Series on Critical Anatomy.

MRI-guided high-intensity focused ultrasound (MRgHIFU) has emerged as an alternative to other neuromodulatory interventions for patients with medicall...

Apr 15 2026 41983872
Augmenting Large Language Model With Prompt Engineering and Supervised Fine-Tuning in Non-Small Cell Lung Cancer Tumor-Node-Metastasis Staging: Framework Development and Validation.

BACKGROUND: Accurate tumor node metastasis (TNM) staging is fundamental for treatment planning and prognosis in non-small cell lung cancer (NSCLC). Ho...

Apr 15 2026 41984624
Fact-Checking Large Language Model Responses to a Health Care Prompt: Comparative Study.

BACKGROUND: Large language models use machine learning to produce natural language. These models have a range of potential applications in health care...

Apr 15 2026 41985066
Integrating Next-Generation Sequencing into von Willebrand Disease Diagnostics: Insights from the PCM-EVW-ES Multicenter Project.

Von Willebrand disease (VWD) is the most common inherited bleeding disorder, caused by quantitative or qualitative defects in von Willebrand factor (V...

Apr 15 2026 41985465
Multidisciplinary blinded randomized expert evaluation of large language models for clinical diagnosis and management.

BACKGROUND: Direct clinical uses of large language models (LLMs) remain controversial, partly because of the lack of methodological rigor in assessing...

Apr 15 2026 41986491
AI-Generated Clinical Images of Head-and-Neck Lesions in Plastic Surgery Education: An Expert Evaluation.

BACKGROUND: Clinical images are essential in plastic and reconstructive surgery education, particularly for understanding pathology, planning reconstr...

Apr 15 2026 41986550
Malignant Cerebral Edema after Large-Core Anterior Circulation Stroke in the Thrombectomy Era: Prediction and Neurocritical Care Pathways.

Large-core anterior circulation ischemic stroke (LCIS) complicated by malignant cerebral edema (MCE) remains a leading cause of early death and profou...

Apr 15 2026 41986793
Food safety assessment of hemipteran-specific insecticidal protein Tpp78Aa from Bacillus thuringiensis.

BACKGROUND: Hemipteran pests pose a significant threat to global agriculture, creating a continuous need for effective and safe control strategies. Tp...

Apr 15 2026 41986881
[Comparative observation of analgesic efficacy between liposomal bupivacaine and "cocktail" therapy following artificial intelligence-assisted direct anterior approach total hip arthroplasty: A prospective randomized controlled study].

OBJECTIVE: To compare the analgesic efficacy and safety of liposomal bupivacaine (LB) versus ropivacaine for surgical incision local anesthesia after ...

Apr 15 2026 41981425
Risk-Guided Atrial Fibrillation Screening With Artificial Intelligence-Enabled Electrocardiogram Models: A VITAL-AF Trial Analysis.

BACKGROUND: Screening for atrial fibrillation (AF) may lead to earlier detection and initiation of preventive measures. Current AF screening approache...

Apr 14 2026 41983618
Contextualizing the Patient Blood Management (PBM) Program Through the Lens of Bioethical Principles.

In an increasingly specialized medical landscape, Patient Blood Management (PBM) has emerged as a multidisciplinary and ethically grounded approach to...

Apr 14 2026 41979213
Hypotension Prediction Index-Guided Hemodynamic Management on Postoperative Organ Outcome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Intraoperative hypotension (IOH) is a frequent occurrence during noncardiac surgery. Hypotensive episodes can compromise tissue perfusion, and cumulat...

Apr 14 2026 41980015
Risk prediction in spine surgery: a scoping review of traditional models, artificial intelligence, and the challenge of clinical translation.

BACKGROUND: Accurate perioperative risk stratification is essential to patient safety and informed consent in spine surgery. Traditional regression-ba...

Apr 13 2026 41973342
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