Clinical Trials

Creation of an mHealth Infrastructure to Support the Development and Delivery of mHealth Interventions: Protocol for Demonstration Projects Addressing Smoking Cessation in Cancer Care.

BACKGROUND: Cancer remains a leading cause of morbidity worldwide. To reduce this burden, scalable, effective approaches are needed to address modifiable risk factors for cancer and support behavioral self-management. With smartphone ownership now nearly ubiquitous, mobile health (mHealth) interventions offer a powerful means to extend the reach, accessibility, and sustainability of evidence-based...

New Frontiers of Drug Development Through the Use of New Approach Methodologies.

On November 2025, AAPS PharmSci 360 convened a symposium that included experts in the application of various types of New Approach Methodologies (NAMs). They shared their experiences and insights on topics that included microphysiological systems (MPS), the use of 3D organoids, and in silico tools. MPS systems were explored from the perspective of their testing and qualification through an academi...

The impact of an artificial intelligence (AI)-assisted education program on mental health, social support and quality of life in older individuals with head and neck cancer: study protocol of a randomized controlled trial.

BACKGROUND: Head and neck cancer (HNC) is a common malignant tumor, and its treatment often leads to functional impairments in speech, swallowing, and...

Toward equitable digital health: an integrated framework addressing exclusion, ethics, and implementation across healthcare systems.

BACKGROUND: Digital health technologies are fundamentally reshaping healthcare delivery, access, and governance worldwide. While these innovations off...

Deep Learning-Based Quantification of Vitreous Hyperreflective Foci as a Biomarker for Intraocular Inflammation.

OBJECTIVE: To develop and validate an artificial intelligence (AI)-driven pipeline to quantify vitreous hyperreflective foci (vHRF) from OCT images an...

Ambient AI Scribes to Create Educational Feedback Notes for Medical Students: Randomized Trial.

BACKGROUND: High-quality observation and feedback contribute to the development of clinical competence and professional growth in medical education. F...

Integrated multi-endpoint hazard prioritization of unregulated industrial contaminants: A safety-first screening framework for emerging environmental threats.

The rapid expansion of the industrial chemical space has outpaced regulatory oversight, creating a critical regulatory and environmental blind spot re...

Language barriers, mobility, and health equity: clinical risks, economic burden, and policy options for universal language access.

BACKGROUND: International mobility has intensified routine contact between health systems and patients who do not speak the dominant language of care....

Traumatic Inflammatory-Coagulation Coactivation Occurs Early After Injury and Impacts Mortality.

OBJECTIVES: Acute traumatic coagulopathy is known to occur early following severe injury. However, the role and impact of both pro- and anti-inflammat...

Nanomedicine-based cancer immunotherapy: translational barriers, mechanistic strategies, and future perspectives.

Nanomedicine-based cancer immunotherapy integrates nanotechnology with immune modulation, representing a promising strategy to improve both the effica...

AI-assisted case-based learning and flipped classroom to improve clinical decision-making: a randomized controlled trial in reproductive medicine.

BACKGROUND: Efficient training of reproductive medicine clinicians is critical in the context of declining global fertility and increasing infertility...

Food-derived components as natural skin-whitening strategies: Classification, mechanisms, application forms and prospects.

BACKGROUND: Skin hyperpigmentation has attracted widespread attention. Traditional chemical skin-whitening components pose potential risks, whereas fo...

Unraveling EFL students' technology self-efficacy, emotions and behavioral intentions in leveraging large language models: the serial mediation of perceptions and attitudes.

With the growing momentum to integrate artificial intelligence (AI) into education, large language models (LLMs) have shown great potential for Englis...

Alignment of Policy, Practice, and Patient Safety for Trustworthy AI in Radiology.

Artificial intelligence (AI) has progressed from technical research to routine clinical use, reaching an inflection point where technological capabili...

Arrhythmia Burden and Clinical Responses Under Continuous Monitoring in Heart Failure: Observations From the ALLEVIATE-HF Trial.

BACKGROUND: Arrhythmia burden in ambulatory patients with symptomatic heart failure (HF) without cardiac implantable electronic devices (CIEDs) is not...

The Next Wave of Workplace Bullying in Health Care.

BACKGROUND AND INTRODUCTION: Workplace bullying and incivility have continued to escalate across health care and pose serious risks to workforce well-...

The VALUE of AI-Guided Communication: Enhancing Shared Decision-Making in Metabolic Bariatric Surgery Consultations Through a Metacognitive Framework.

BACKGROUND: Effective communication in metabolic bariatric surgery (MBS) is essential for patient engagement and adherence, yet surgical residents oft...

State-dependent neuromodulation reveals link between online and offline corticospinal excitability.

The post-intervention effects of non-invasive neuromodulation techniques are critical for their translational potential in neurorehabilitation and dep...

AI-Generated Avatar Videos for Postoperative Patient Education Among Health Care Workers: Pilot Randomized Controlled Trial.

BACKGROUND: Effective postoperative communication is vital for patient recovery, yet traditional text-based discharge instructions often lead to poor ...

Reducing Mis-triage in Emergency Departments (RemEDy): Protocol for Improving Triage Accuracy Through Real-time Evaluation and Artificial Intelligence.

BACKGROUND: Mis-triage represents a global concern, with reported rates ranging from 15% to 33%. Understanding its causes and contributing factors is ...