COPD

Outcome of Inhaler Withdrawal in Patients Receiving Triple Therapy for COPD.

BACKGROUND: The purpose of this study was to document outcomes following withdrawal of a single inhaler (step-down) in chronic obstructive pulmonary disease (COPD) patients on triple therapy (long-acting muscarinic antagonist and a combination of long-acting β2-agonists and inhaled corticosteroid), which a common treatment strategy in clinical practice.

Layer-by-layer assembly of gold nanoparticles and cysteamine on gold electrode for immunosensing of human chorionic gonadotropin at picogram levels.

The development of an electrochemical immunosensor for the detection of human chorionic gonadotropin (hCG) is described with a limit of detection as low as 0.3 pg mL(-1) in phosphate buffer. In this immunosensor, cysteamine (Cys) and gold nanoparticles (AuNPs) were used to immobilize an anti-hCG monoclonal antibody onto a gold electrode (GE). The structure of AuNPs has been confirmed by EDS, SEM, ...

Nanocomposites of gold nanoparticles and graphene oxide towards an stable label-free electrochemical immunosensor for detection of cardiac marker troponin-I.

A stable label-free amperometric immunosensor is presented based on gold nanoparticles and graphene oxide nanocomposites for detection of cardiac trop...

DNA methyltransferase detection based on digestion triggering the combination of poly adenine DNA with gold nanoparticles.

DNA methyltransferase (MTase) has received a large amount of attention due to its catalyzation of DNA methylation in both eukaryotes and prokaryotes, ...

The Athlete's Brain: Cross-Sectional Evidence for Neural Efficiency during Cycling Exercise.

The "neural efficiency" hypothesis suggests that experts are characterized by a more efficient cortical function in cognitive tests. Although this hyp...

A "Turn-on-off-on" fluorescence switch based on quantum dots and gold nanoparticles for discriminative detection of ovotransferrin.

A novel strategy for ovotransferrin (OVT) detection by tracing the "on-off-on" fluorescence signals of quantum dots (QDs) and gold nanoparticles (AuNP...

Sensitive and versatile electrogenerated chemiluminescence biosensing platform for protein kinase based on Ru(bpy)3(2+) functionalized gold nanoparticles mediated signal transduction.

A novel, sensitive and versatile electrogenerated chemiluminescence biosensing platform is developed for monitoring activity and inhibition of protein...

Estimation of extravascular lung water using the transpulmonary ultrasound dilution (TPUD) method: a validation study in neonatal lambs.

Increased extravascular lung water (EVLW) may contribute to respiratory failure in neonates. Accurate measurement of EVLW in these patients is limited...

Neuro-fuzzy classification of asthma and chronic obstructive pulmonary disease.

BACKGROUND: This paper presents a system for classification of asthma and chronic obstructive pulmonary disease (COPD) based on fuzzy rules and the tr...

Annotating longitudinal clinical narratives for de-identification: The 2014 i2b2/UTHealth corpus.

The 2014 i2b2/UTHealth natural language processing shared task featured a track focused on the de-identification of longitudinal medical records. For ...

Pharmacokinetics of aclidinium bromide/formoterol fumarate fixed-dose combination compared with individual components: A phase 1, open-label, single-dose study.

Inhaled, long-acting bronchodilators represent a cornerstone of maintenance treatment for chronic obstructive pulmonary disease (COPD). Aclidinium bro...

Combining expert knowledge and knowledge automatically acquired from electronic data sources for continued ontology evaluation and improvement.

INTRODUCTION: A common bottleneck during ontology evaluation is knowledge acquisition from domain experts for gold standard creation. This paper contr...

On the creation of a clinical gold standard corpus in Spanish: Mining adverse drug reactions.

The advances achieved in Natural Language Processing make it possible to automatically mine information from electronically created documents. Many Na...

Annotating risk factors for heart disease in clinical narratives for diabetic patients.

The 2014 i2b2/UTHealth natural language processing shared task featured a track focused on identifying risk factors for heart disease (specifically, C...

A multilingual gold-standard corpus for biomedical concept recognition: the Mantra GSC.

OBJECTIVE: To create a multilingual gold-standard corpus for biomedical concept recognition.

Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.

Because of unique optical behavior gold nanorods (GNRs) have attracted attention for the application in biomedical field such as bio-sensing, bio-imag...

Machine learning algorithms and forced oscillation measurements to categorise the airway obstruction severity in chronic obstructive pulmonary disease.

The purpose of this study was to develop automatic classifiers to simplify the clinical use and increase the accuracy of the forced oscillation techni...

Effects of steep Trendelenburg position for robotic-assisted prostatectomies on intra- and extrathoracic airways in patients with or without chronic obstructive pulmonary disease.

BACKGROUND: The use of the steep Trendelenburg position and abdominal CO2-insufflation during surgery can lead to significant reduction in pulmonary c...

Technology advances in hospital practices: robotics in treatment of patients.

Laparoscopic cholecystectomy is widely considered as the treatment of choice for acute cholecystitis. The safety of the procedure and its minimal inva...

A Multi-Agent Large Language Model Reasoning Engine for Early Detection of Pediatric Growth Disorders

Routine childhood growth surveillance is a cornerstone of pediatric care. Growth pattern abnormalities are often early manifestations of chronic disea...