Latest AI and machine learning research in covid-19 for healthcare professionals.
Mapping conformational B-cell epitopes remains a central challenge for antibody discovery: experimen...
The Clinical Interpretation of Variants in Cancer (CIViC) knowledgebase provides a community-driven,...
Sleep disturbances have been shown to be intimately and bidirectionally related to disease progressi...
Accurate in silico identification of B-cell epitope residues is crucial for antibody design and stru...
B7-H3 (CD276), an immunoregulatory checkpoint molecule overexpressed in numerous cancers, is a promi...
Polymerase Chain Reaction (PCR) is a widely used molecular biology technique to amplify DNA sequence...
Antibodies play a crucial role in adaptive immunity. They develop as B cell receptors (BCRs): membra...
Late-stage failures of monoclonal antibody (mAb) programs often reflect developability liabilities, ...
Antibodies must bind their targets with high affinity and specificity to achieve useful therapeutic ...
Previously, we proposed a double-point mutation (DPM) strategy involving the simultaneous substituti...
T7 RNA polymerase (T7 RNAP) is a foundational enzyme for biotechnology, but its utility for many pot...
Therapeutic antibody design is a complex multi-property optimization problem with substantial promis...
Antibodies are central to immune defense and therapeutic design, yet predicting which sequences conf...
SpliceAI has become the leading computational tool for predicting splice-altering variants, but rest...
Designing effective vaccination strategies against genetically diverse viruses, such as HIV or influ...
Complex multilineage organoid systems lack quantitative phenotyping methods preserving spatial archi...
Enzyme engineering is central to developing biocatalysts with improved activity and specificity, yet...
Mosaic variants, defined as postzygotic mutations occurring during an organism’s development from zy...
Accurately predicting gene expression from DNA sequence remains a central challenge in human genetic...
Genomic technology advancements have facilitated associations between genetic variants and disease r...
Class I major histocompatibility complexes (MHCs), expressed on the surface of all nucleated cells, ...