Latest AI and machine learning research in dementia for healthcare professionals.
Tau-protein aggregation is a central pathological feature of Alzheimer's disease, so blocking fibril growth is an attractive therapeutic goal. We curated a high-quality set of 289 literature IC50  measurements for human-tau aggregation and trained a stacked-ensemble QSAR model (SVR + RF + XGB) that achieves fivefold CV Q2 = 0.63, external R2 = 0.57 and RMSE = 0.73 log-units. Applicability-domain a...
Generative artificial intelligence (AI) technologies, capable of producing original text, images, audio, and video, are increasingly embedded in children's learning, play, and daily life. Pediatric clinicians and parents face the challenge of guiding children toward safe and constructive engagement with these rapidly evolving tools. This state-of-the-art review synthesizes current knowledge regard...
Symptoms of anxiety are known to be triggered by a range of life context factors including early life trauma, poor sleep quality, infrequent exercise,...
BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β plaques, neurofibrillary tangles, and synapt...
Dementia is a progressive neurodegenerative disorder that severely impacts cognitive functions and daily living, especially in aging populations. Amon...
Infants' time spent in different body positions varies substantially within a day: lying supine on their backs, crawling or playing while prone on the...
Faces provide crucial input for early development. This study leveraged innovations in wearable head-mounted cameras (headcams; specifically, TinyExpl...
Episodic memory integrates what, where, and when of experience into a coherent autobiographical narrative. Decades of research have identified hippoca...
OBJECTIVES: Assessing regional brain atrophy on 3D-T1w imaging is crucial for evaluating neurodegenerative disorders. However, high-quality volumetric...
This work describes BlindSpot-VisionGuide, an integrated, AI-based assistive system that aims to empower visually impaired people towards independence...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder increasingly associated with peripheral inflammatory conditions such as chronic p...
Alzheimer's disease (AD) involves proteostasis dysregulation causing protein misfolding, but whether these structural changes manifest as plasma confo...
INTRODUCTION: Alzheimer's disease (AD) is characterized by significant brain atrophy, detectable via structural MRI. There has been less focus on cort...
BACKGROUND: Atrial cardiopathy often precedes atrial fibrillation (AF) and has emerged as an independent risk factor for cardiovascular outcomes. Howe...
BACKGROUND: The integration of retrieval-augmented generation (RAG) systems into the domain of medical question-answering (QA) presents a significant ...
BACKGROUND: The global population of People Living with Dementia (PLWD) is expected to grow rapidly in the coming decades, increasing the need for per...
Alzheimer's disease (AD) is a powerful neurodegenerative disease characterized by cholinergic deficiency, where the inhibition of acetylcholinesterase...
Psychotic disorders are marked by heterogeneity in symptoms and treatment response, yet efforts to develop clinically useful predictive models through...
BACKGROUND AND OBJECTIVE: Early and correct classification of neurodegenerative diseases like Alzheimer's Disease (AD) and Frontotemporal Dementia (FT...
BACKGROUND: The memory assessment pathway (MAP) for people with subjective memory deficits (dementia, mild cognitive impairment, and other diagnoses) ...