Devices and Vaccines

Quorum-sensing, microbiome interactions, and emerging artificial intelligence-assisted anti-virulence strategies in Salmonella Typhi: a critical review of translational opportunities and challenges.

Typhoid fever, caused by Salmonella enterica subsp. enterica serovar Typhi (Salmonella Typhi), remains a significant global health challenge that is increasingly complicated by the emergence and spread of multidrug-resistant (MDR) and extensively drug-resistant strains. Growing limitations of antibiotic-centered treatment strategies have stimulated interest in anti-virulence approaches targeting b...

A Novel Convolutional Neural Network-Based Algorithm for Heart Rate Measurement From Ballistocardiography Signals in Diverse Clinical Settings: Observational Study.

BACKGROUND: Continuous vital sign monitoring ensures early detection, prevents intensive care unit (ICU) admissions, and improves patient outcomes. Continuous heart rate (HR) monitoring methods often require direct skin contact, which can lead to patient discomfort. The rising popularity of ballistocardiography (BCG) offers a promising, noncontact solution for continuous vital sign monitoring with...

Regulatory Approaches to Cybersecurity Risk Management for AI-Enabled Medical Device Software in Korea, the United States, and the European Union: Comparative Document Analysis.

BACKGROUND: Software-based and AI-enabled medical devices are increasingly networked and updatable, expanding the attack surface and making cybersecur...

Perception and encoding of narrative events during continuous speech listening in background noise.

Everyday speech comprehension involves interpreting overarching themes as they unfold continuously overtime and structuring experiences for effective ...

[Diagnostic performance of a dual-stage deep learning model based on cone beam CT-derived multi-view two-dimensional slices for assessing ankylosed impacted teeth].

Objective: To develop and validate a dual-layer deep learning model based on cone-beam CT (CBCT)-derived multi-view two-dimensional (2D) slices for th...

Neonatal Bloodstream Infections: A Narrative Review on Diagnostic and Therapeutic Challenges and Prospects in Developing Countries.

BACKGROUND: Bloodstream infections (BSIs) pose a significant global health challenge, particularly in developing countries. Neonates are highly vulner...

From fragmented records to living evidence: health system-governed, artificial intelligence-driven, continuously updated real-world clinical data from Truveta.

OBJECTIVES: Real-world data (RWD) have historically suffered from fragmentation, delayed availability, variable data quality, and limited analytic uti...

Wellens' Sign and Syndrome Detected With the Home Use of a Novel 12-Lead Electrocardiogram.

BACKGROUND: Wellens' sign is a high-risk electrocardiogram (ECG) pattern associated with proximal left anterior descending artery stenoses and high ri...

Predetermined Change Control Plan Adoption and Documentation Transparency in FDA-cleared Radiology Artificial Intelligence/Machine Learning Devices.

Purpose To characterize Predetermined Change Control Plan (PCCP) adoption and documentation transparency among U.S. Food and Drug Administration (FDA)...

Artificial intelligence for pediatric fracture detection: impact on diagnostic revisions and patient recall rates in a tertiary emergency setting.

PURPOSE: Artificial intelligence (AI) can support and enhance radiologists in musculoskeletal imaging, but evidence of clinical benefit is still lacki...

ViralMap: predicting features in viral proteins from primary sequence.

Modern viral vaccines are designed to elicit an immune response against viral proteins that mediate infection, making those proteins important targets...

Automated classification of dental implant brands and prosthetic platform sizes on panoramic radiographs using deep learning.

STATEMENT OF PROBLEM: Incomplete clinical records can be a significant hurdle in implant dentistry, transforming routine maintenance or a restorative ...

The Role of Pharmacists in Tackling Mpox: Challenges and Future Prospects: A Narrative Review.

BACKGROUND AND AIMS: Pharmacists play a key role in managing and mitigating mpox through clinical care, pharmacovigilance, vaccine management, and res...

A 3-year wastewater-based epidemiology study of noroviruses in Senegal.

UNLABELLED: Norovirus is a leading cause of acute gastroenteritis worldwide due to its high contagiousness, widespread transmission, and the lack of t...

ImplantPlanNet: A deep learning framework for automatic implant planning from preoperative CBCT images.

OBJECTIVES: Preoperative implant planning based on cone-beam computed tomography (CBCT) images supports prosthetically driven treatment but remains ti...

IDEAL-Age: an interpretable deep learning framework for single-cell resolution profiling of immunological aging.

Immunosenescence increases susceptibility to infection and reduces vaccine responsiveness, yet bulk transcriptomic clocks obscure the cellular heterog...

Mapping the global research landscape and knowledge structure of robotic-assisted dental, oral and maxillofacial surgery: a bibliometric analysis.

To systematically characterize the global research landscape, collaboration patterns, and emerging trends in robotic-assisted dental, oral and maxillo...

Cross-Device Risk Calibration for Surface-Enhanced Raman Spectroscopy-Based Urologic Disease Classification.

Surface-enhanced Raman spectroscopy (SERS) combined with deep learning offers a noninvasive route for molecular screening of urologic diseases. Its br...

Systematic Benchmarking of CRISPR-Cas9 Off-Target Prediction Tools Reveals Limitations and Implications for Preclinical Assessment.

Accurate identification of CRISPR-Cas9 off-target sites is essential for the safety assessment of genome-editing-based therapies. While numerous in si...

What Would Be the Ideal Robotic Companion in Orthopaedic Surgery in 10 Years?

BACKGROUND: Robotic-assisted surgery is now an established part of contemporary orthopaedic practice, particularly in knee arthroplasty, where it has ...