Diabetes

Integrated network pharmacology and bioinformatics analysis reveals MME as key target of Notoginsenoside R1 in diabetic nephropathy.

BACKGROUND: Diabetic nephropathy (DN) is a major diabetes complication and a primary cause of end-stage renal failure. Notoginsenoside R1 (NGR1) is known to reduce proteinuria, exert hypoglycemic effects, and enhance renal function in DN patients. However, the exact mechanisms by which NGR1 affects DN are not well understood. METHODS: An integrative approach combining multi-omics bioinformatics an...

Artificial Intelligence in Nutrigenomics: A Critical Review on Functional Food Insights and Personalized Nutrition Pathways.

BACKGROUND: This review critically evaluates the applications of artificial intelligence in nutrigenomics, focusing on its role in interpreting functional food-gene interactions, supporting personalized nutrition strategies, and enabling evidence-based dietary interventions for improved health outcomes. METHODS: A systematic literature search was conducted using PubMed, Scopus, Web of Science, and...

Artificial Intelligence-derived Measurements of Myosteatosis from Coronary Artery Calcium CT Scans to Predict COPD: The Multi-Ethnic Study of Atherosclerosis.

Purpose To evaluate the predictive value of myosteatosis as an opportunistic finding in coronary artery calcium (CAC) CT scans for clinically diagnose...

A Deep Learning Framework for Predicting Teprotumumab Treatment Response in Thyroid Eye Disease.

PURPOSE: To develop and evaluate a deep learning-based framework for quantifying thyroid eye disease (TED) severity before and after teprotumumab trea...

C-X-C Motif Chemokine Ligand 3 as a Potential Biomarker for Diagnosis and Prognosis of Diabetic Kidney Disease.

Diabetic kidney disease (DKD) is the primary cause of end-stage renal disease globally, yet reliable biomarkers for its diagnosis and progression asse...

COL14A1 drives ischemic cardiac injury in PCOS: an artificial intelligence-identified biomarker.

BACKGROUND: Polycystic ovary syndrome (PCOS) and ischemic cardiomyopathy (ICM) share metabolic and cardiovascular risk factors, including insulin resi...

Stress hyperglycemia ratio and mortality risk in cardiometabolic multimorbidity: a multicenter retrospective study.

Characterizing the Immune Cell Infiltration in Renal Interstitium and Therapeutic Targets of Drugs in Diabetic Nephropathy by Multiomics Study.

BACKGROUND: Immune cell infiltration in the renal interstitium contributes to the progression of diabetic nephropathy (DN), yet the precise mechanisms...

Predictive Performance of Artificial Intelligence Algorithms for Gestational Diabetes Mellitus in Pregnant Women: Systematic Review and Meta-Analysis.

BACKGROUND: Gestational diabetes mellitus (GDM) is a common complication during pregnancy, with its incidence increasing year by year. It poses numero...

Artificial Intelligence-Based Medical Devices for Diabetic Retinopathy Screening in the European Union.

BACKGROUND: Diabetic retinopathy (DR) remains a leading cause of preventable blindness, yet screening programs across Europe face persistent workforce...

Machine learning-driven identification of shared and disease-specific mitochondria-related genes in COPD, NSCLC, and NSCLC with COPD.

Chronic obstructive pulmonary disease (COPD) and non-small-cell lung cancer (NSCLC) often coexist; here, the shared mitochondrial drivers were investi...

A CT-based radiomics model for classification of chronic pancreatitis: new biomarkers for diagnosis and severity staging.

OBJECTIVES: To develop and validate CT-based radiomics models for the identification of chronic pancreatitis (CP) and selected CP-related complication...

Double Graph Attention Network for predicting non-alcoholic fatty liver disease in patients with type 2 diabetes.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, while non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver di...

Explainable reinforcement learning for glucose monitoring based on shapley value analysis.

BACKGROUND AND OBJECTIVE: Effective diabetes management requires continuous regulation of blood glucose in response to complex factors such as diet, a...

Characterization of Models for Identifying Physical and Cognitive Frailty in Older Adults With Diabetes: Systematic Review and Meta-Analysis.

BACKGROUND: Physical frailty and cognitive frailty are increasingly recognized as critical geriatric syndromes among older adults with diabetes, contr...

Optimizing Early Detection of Diabetic Kidney Disease through Synergistic Biomarkers and Serum Metabolites in Human.

BACKGROUND: Diabetic kidney disease (DKD) progresses to end-stage renal disease more rapidly than chronic kidney disease due to persistent hyperglycem...

Development of a machine learning-based model for prediction of diabetes risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading chronic liver disorder closely linked to diabetes mellitus (...

Key evidence for personalised nutrition: a review of randomised controlled trials.

The field of personalised nutrition is growing and is based on the concept that delivering personalised dietary advice will be more effective than gen...

Bioinspired Multifunctional Hydrogels for Deep Learning-Enabled Wound pH Visual Monitoring and Treatment.

Smart wound dressings capable of real-time environmental monitoring and therapeutic intervention are crucial for managing difficult-to-heal wounds. He...

Prognostic value of the triglyceride-glucose index combined with atherogenic index of plasma for all-cause mortality in critically ill patients with chronic heart failure: a machine learning-driven retrospective cohort study.

BACKGROUND: The triglyceride-glucose index (TyG) and atherogenic index of plasma (AIP) are emerging metabolic biomarkers associated with cardiovascula...