Endocrinology

Latest AI and machine learning research in endocrinology for healthcare professionals.

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Interpretable Predictive Modeling for Medical Data Using Boolean Rule-aware Regression

Purpose: In clinical practice, accurate prediction of disease risk must be accompanied by transparent, human-understandable explanations to support diagnostic confidence, guide therapeutic decisions, and meet ethical and regulatory standards. While deep neural networks achieve high predictive performance in tasks such as cancer detection and diabetes risk stratification, their black-box nature pre...

Elevated serum apolipoprotein B and lipoprotein remodelling distinguish adults with HLH from HLH mimics and controls

Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome characterised by uncontrolled immune activation. Reduced high- and low-density lipoprotein cholesterol and hypertriglyceridaemia are reported in HLH, suggesting lipid metabolism disturbances although in-depth serum metabolomic analysis is lacking in HLH. Here a lipid-focused NMR spectroscopy platform w...

Correcting heterogeneous diagnostic bias when developing clinical prediction models using causal hidden Markov models

In routine care, individuals identified a priori as high-risk are usually tested for conditions more frequently. Protected attributes, such as sex or ...

May 7 2026 2605.06059v1
Artificial Intelligence Driven Support and Self Care Competence as Determinants of Medication Adherence in Diabetes Care, A Cross-sectional Nigerian Study

Medication adherence among patients with diabetes remains suboptimal in low and middle income countries, including Nigeria. Emerging digital health in...

Claim-Level Transparency Analysis of LLM-Generated Diagnostic Reports: A Metabolic and Endocrine Biomarker Study

Large language models are increasingly deployed in clinical decision-support contexts, yet systematic evaluation of their factual reliability in gener...

A Digital Twin for Tracking and Forecasting Glycemia with Septic Patients in ICUs

We present a digital twin framework for real time glucose monitoring and forecasting in septic patients in intensive care units (ICUs). The framework ...

From Prediction to Practice: A Task-Aware Evaluation Framework for Blood Glucose Forecasting

Clinical time-series forecasting is increasingly studied for decision support, yet standard aggregate metrics can obscure whether a model is actually ...

May 1 2026 2605.00645v1
Prediction of Alzheimer's Disease Risk Factors from Retinal Images via Deep Learning: Development and Validation of Biologically Relevant Morphological Associations in the UK Biobank

The systemic, metabolic, lifestyle factors have established associations with Alzheimer's Disease (AD) through epidemiologic and AD-specific biomarker...

May 1 2026 2605.00665v1
Population geometry reveals directed coupling and transient bistability in spontaneous pituitary secretion

The pituitary gland operates as an organized signaling network in which endocrine cell populations coordinate hormone secretion, through homotypic and...

Development and validation of a lesion-supervised deep learning system for diabetic retinopathy grading according to UK national screening criteria

Background: Diabetic retinopathy (DR) is the leading cause of preventable blindness among working-age adults worldwide, yet screening coverage remains...

Development of Explainable Machine Learning Framework for Early Detection and Risk Stratification of Diabetes in Age Specific Variations

Objective To develop and evaluate a novel machine learning (ML) framework tailored to a clinical diabetes dataset and to assess whether demographic st...

Integrative Bioinformatics Approach to Identify Prognostic Gene Signatures for Risk Stratification in Thyroid Carcinoma

Thyroid cancer is a heterogeneous malignancy with variable outcomes, highlighting the need for reliable biomarkers and effective risk stratification. ...

An empirical evaluation of the risks of AI model updates using clinical data: stability, arbitrariness, and fairness

Artificial Intelligence and Machine Learning (AI/ML) models used in clinical settings are increasingly deployed to support clinical decision-making. H...

Apr 27 2026 2604.23954v1
Impact of Age Specialized Models for Hypoglycemia Classification

Disease progression varies with age and is influenced by underlying genetic, biochemical, and hormonal etiologies, suggesting the need for tailored mo...

Apr 26 2026 2604.23732v1
Semaglutide is associated with improved breast cancer survival, lower metastatic burden, and a dose-survival relationship uncoupled from weight-loss magnitude

Metabolic dysfunction is increasingly recognized as a risk factor for poor outcomes in breast cancer, but whether incretin-based therapies confer surv...

Multimodal prediction of visual improvement in diabetic macular edema using real-world electronic health records and optical coherence tomography images

Multimodal learning has the potential to improve clinical prediction by integrating complementary data sources, but the incremental value of imaging b...

Liver Biomarker Improves AHA/ACC 10-year ASCVD Risk Prediction in US and China Cohorts with ML

Introduction: Accurate stratification of hard atherosclerotic cardiovascular disease (ASCVD) risk remains challenging despite advances in prevention. ...

an interpretable vision transformer framework for automated brain tumor classification

Brain tumors represent one of the most critical neurological conditions, where early and accurate diagnosis is directly correlated with patient surviv...

Apr 23 2026 2604.21311v1
Robust Diabetic Retinopathy Grading Using Dual-Resolution Attention-Based Deep Learning with Ordinal Regression

Diabetic retinopathy (DR) is a leading cause of vision impairment worldwide, and automated grading systems play a crucial role in large-scale screenin...

Apr 19 2026 2604.17341v1
Imbalance-Aware Optimal Transport Learning for Cost-Effective Diabetic Retinopathy Screening

Abstract Background Diabetic Retinopathy (DR) is one of the leading cause of vision loss and blindness. AI models have been instrumental in providing ...

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